5 documents found, page 1 of 1
Staining of E-Selectin Ligands on Paraffin-Embedded Sections of Tumor Tissue
Carrascal, M; Talina, C; Borralho, P; Gonçalo Mineiro, A; Henriques, AR; Pen, C; Martins, M; Braga, S; Sackstein, R; Videira, PBACKGROUND: The E-selectin ligands expressed by cancer cells mediate adhesion of circulating cancer cells to endothelial cells, as well as within tissue microenvironments important for tumor progression and metastasis. The identification of E-selectin ligands within cancer tissue could yield new biomarkers for patient stratification and aid in identifying novel therapeutic targets. The determinants of selectin ...
Inhibition of Fucosylation in Human Invasive Ductal Carcinoma Reduces E-Selecti...
Carrascal, M; Silva, M; Ramalho, J; Pen, C; Martins, M; Pascoal, C; Amaral, C; Serrano, I; Oliveira, MJ; Sackstein, R; Videira, PBreast cancer tissue overexpresses fucosylated glycans, such as sialyl-Lewis X/A (sLeX/A ), and α-1,3/4-fucosyltransferases (FUTs) in relation to increased disease progression and metastasis. These glycans in tumor circulating cells mediate binding to vascular E-selectin, initiating tumor extravasation. However, their role in breast carcinogenesis is still unknown. Here, we aimed to define the contribution of t...
Oxidative damage and response to Bacillus Calmette-Guérin in bladder cancer cel...
Severino, P; Silva, M; Carrascal, M; Malagolini, N; Chiricolo, M; Venturi, G; Barbaro Forleo, R; Astolfi, A; Catera, M; Videira, P; Dall'Olio, FTreatment with Bacillus Calmette-Guérin (BCG) is the gold standard adjuvant immunotherapy of non-muscle invasive bladder cancer (NMIBC), although it fails in one third of the patients. NMIBC expresses two tumor-associated O-linked carbohydrates: the disaccharide (Galß1,3GalNAc) Thomsen-Friedenreich (T) antigen, and its sialylated counterpart (Siaa2,3Galß1,3GalNAc) sialyl-T (sT), synthesized by sialyltransferase...
Inhibition of fucosylation in human invasive ductal carcinoma reduces E-selecti...
Carrascal, M; Silva, M; Ramalho, J; Pen, C; Martins, M; Pascoal, C; Amaral, C; Serrano, I; Oliveira, MJ; Sackstein, R; Videira, PBreast cancer tissue overexpresses fucosylated glycans, such as sialyl-Lewis X/A (sLeX/A), and a-1,3/4-fucosyltransferases (FUTs) in relation to increased disease progression and metastasis. These glycans in tumor circulating cells mediate binding to vascular E-selectin, initiating tumor extravasation. However, their role in breast carcinogenesis is still unknown. Here, we aimed to define the contribution of th...
Sialyl Tn-Expressing Bladder Cancer Cells Induce a Tolerogenic Phenotype in Inn...
Carrascal, M; Severino, P; Cabral, MG; Silva, M; Ferreira, JA; Calais da Silva, F; Quinto, H; Pen, C; Ligeiro, D; Lara Santos, L; Dall'Olio, FDespite the wide acceptance that glycans are centrally implicated in immunity, exactly how they contribute to the tilt immune response remains poorly defined. In this study, we sought to evaluate the impact of the malignant phenotype-associated glycan, sialyl-Tn (STn) in the function of the key orchestrators of the immune response, the dendritic cells (DCs). In high grade bladder cancer tissue, the STn antigen ...