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CuMV VLPs Containing the RBM from SARS-CoV-2 Spike Protein Drive Dendritic Cell...
Sebastião, Ana Isabel; Mateus, Daniela; Carrascal, Mylène A.; Sousa, Cátia; Cortes, Luísa; Bachmann, Martin F; do Carmo, Anália; Matos, Ana M.Dendritic cells (DCs) are the most specialized and proficient antigen-presenting cells. They bridge innate and adaptive immunity and display a powerful capacity to prime antigen-specific T cells. The interaction of DCs with the receptor-binding domain of the spike (S) protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a pivotal step to induce effective immunity against the S protei...
Antitumor Activity of Fucus vesiculosus-Derived Phlorotannins through Activatio...
Catarino, Marcelo D.; Fernandes, Iva; Oliveira, Hélder; Carrascal, Mylène A.; Ferreira, Rita; Silva, Artur M. S.; Cruz, Maria Teresa; Mateus, NunoSeaweeds are one of the largest producers of biomass in the marine environment and a source of multiple bioactive metabolites with valuable health benefits. Among these, phlorotannins have been widely recognized for their promising bioactive properties. The potential antitumor capacity of Fucus vesiculosus-derived phlorotannins remains, however, poorly explored, especially in gastrointestinal tract-related tumo...
Pharmacological combination of nivolumab with dendritic cell vaccines in cancer...
Calmeiro, João; Carrascal, Mylène A.; Tavares, Adriana Ramos; Ferreira, Daniel Alexandre; Gomes, Célia; Cruz, Maria Teresa; Falcão, AmílcarIn the last decade, immunotherapy led to a paradigm shift in the treatment of numerous malignancies. Alongside with monoclonal antibodies blocking programmed cell death receptor-1 (PD-1)/PD-L1 and cytotoxic T- lymphocyte antigen 4 (CTLA-4) immune checkpoints, cell-based approaches such as CAR-T cells and dendritic cell (DC) vaccines have strongly contributed to pushing forward this thrilling field. While initia...
In-Depth Analysis of the Impact of Different Serum-Free Media on the Production...
Calmeiro, João; Mendes, Luís; Duarte, Iola F.; Leitão, Catarina; Tavares, Adriana R.; Ferreira, Daniel Alexandre; Gomes, Célia; Serra, JoãoDendritic cell (DC)-based antitumor vaccines have proven to be a safe approach, but often fail to generate robust results between trials. Translation to the clinic has been hindered in part by the lack of standard operation procedures for vaccines production, namely the definition of optimal culture conditions during ex-vivo DC differentiation. Here we sought to compare the ability of three clinical grade serum...
Calcium Modulation, Anti-Oxidant and Anti-Inflammatory Effect of Skin Allergens...
Silva, Ana; Pereira, Marta; Carrascal, Mylène A.; Brites, Gonçalo; Neves, Bruno; Moreira, Patrícia; Resende, Rosa; Silva, Maria ManuelExperimental evidence highlights nuclear factor (erythroid-derived 2)-like 2 (Nrf2) as a molecular target in Alzheimer's disease (AD). The well-known effect of electrophilic cysteine-reactive skin allergens on Nrf2-activation led to the hypothesis that these compounds could have a therapeutic role in AD. This was further supported by the neuroprotective activity of the skin allergen dimethyl fumarate (DMF), dem...
Dendritic Cell Vaccines for Cancer Immunotherapy: The Role of Human Conventiona...
Calmeiro, João; Carrascal, Mylène A.; Tavares, Adriana Ramos; Ferreira, Daniel Alexandre; Gomes, Célia; Falcão, Amílcar; Cruz, Maria TeresaThroughout the last decades, dendritic cell (DC)-based anti-tumor vaccines have proven to be a safe therapeutic approach, although with inconsistent clinical results. The functional limitations of ex vivo monocyte-derived dendritic cells (MoDCs) commonly used in these therapies are one of the pointed explanations for their lack of robustness. Therefore, a great effort has been made to identify DC subsets with s...
Biomaterial-based platforms for in situ dendritic cell programming and their us...
Calmeiro, João; Carrascal, Mylène A.; Gomes, Célia; Falcão, Amílcar C.; Cruz, Maria Teresa; Neves, Bruno MiguelDendritic cells (DCs) are central players in the immune system, with an exquisite capacity to initiate and modulate immune responses. These functional characteristics have led to intense research on the development of DC-based immunotherapies, particularly for oncologic diseases. During recent decades, DC-based vaccines have generated very promising results in animal studies, and more than 300 clinical assays h...