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Del pensamiento tirano a vivir la emoción. Psicodrama en grupo con personas dia...

Favero, Marisalva; Gonzalez, Félix; Benavides, Candela; Carrasco, Marta; Orsucci, Antonella; Navarro Roldan, Natacha

Este trabajo pretende aportar nuevas perspectivas e interrogantes sobre la práctica psicodramática, así como valorar la experiencia de la colaboración entre ambos métodos cognitivo conductual y psicodramático en pacientes diagnosticados con trastorno obsesivocompulsivo (TOC).


Probing the aurone scaffold against Plasmodium falciparum: design, synthesis an...

Carrasco, Marta; Newton, Ana; Gonçalves, Lídia; Góis, Ana; Machado, Marta; Gut, Jiri; Nogueira, Fátima; Hanscheid, Thomas; Guedes, Rita C.

A library comprising 44 diversely substituted aurones derivatives was synthesized by straightforward aldol condensation reactions of benzofuranones and the appropriately substituted benzaldehydes. Microwave enhanced synthesis using palladium catalyzed protocols was introduced as a powerful strategy for extending the chemical space around the aurone scaffold. Additionally, Mannich-base derivatives, containing a ...


Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene...

Rodrigues, Tiago; Guedes, Rita C.; dos Santos, Daniel J. V. A.; Carrasco, Marta; Gut, Jiri; Rosenthal, Philip J.; Moreira, Rui; Lopes, Francisca

(1H-Pyridin-4-ylidene)amines containing lipophilic side chains at the imine nitrogen atom were prepared as potential clopidol isosteres in the development of antimalarials. Their antiplasmodial activity was evaluated in vitro against the Plasmodium falciparum W2 (chloroquine-resistant) and FCR3 (atovaquone-resistant) strains. The most active of these derivatives, 4m, had an IC50 of 1 mu M against W2 and 3 mu M ...


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