4 documents found, page 1 of 1
Microbiota derived metabolites from dietary phenolics and their potential to mi...
Carregosa, DiogoResumo: As doenças neurodegenerativas são doenças crónicas com um aumento em incidência, que roubam qualidade de vida e implicam um grande peso aos pacientes, família e ao sistema nacional de saúde. Estas doenças permanecem sem cura, e terapias perdem eficácia com o tempo. Dentro das principais características das doenças neurodegenerativas, neuro inflamação toma uma posição preponderante e comum a várias doenç...
Dietary (Poly)phenols in Traumatic Brain Injury
Carecho, Rafael; Carregosa, Diogo; Ratilal, Bernardo Oliveira; Figueira, Inês; Ávila-Gálvez, María Ángeles; Nunes Dos Santos, ClaudiaFunding Information: This research was funded by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program under grant agreement No 804229. iNOVA4Health Research Unit (LISBOA-01-0145-FEDER-007344), which is co-funded by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Ciência e do Ensino Superior, through national funds, and by FEDER under the PT2020 Par...
Dietary (poly)phenols in traumatic brain injury
Carecho, Rafael; Carregosa, Diogo; Ratilal, Bernardo; Figueira, Inês; Ávila-Gálvez, Maria Angeles; dos Santos, Cláudia NunesTraumatic brain injury (TBI) remains one of the leading causes of death and disability in young adults worldwide. Despite growing evidence and advances in our knowledge regarding the multifaceted pathophysiology of TBI, the underlying mechanisms, though, are still to be fully elucidated. Whereas initial brain insult involves acute and irreversible primary damage to the brain, the processes of subsequent seconda...
5-(Hydroxyphenyl)-γ-Valerolactone-Sulfate, a Key Microbial Metabolite of Flavan...
Angelino, Donato; Carregosa, Diogo; Domenech-Coca, Cristina; Savi, Monia; Figueira, Inês; Brindani, Nicoletta; Jang, Saebyeol; Lakshman, SuklaPhenolic compounds have been recognized as promising compounds for the prevention of chronic diseases, including neurodegenerative ones. However, phenolics like flavan-3-ols (F3O) are poorly absorbed along the gastrointestinal tract and structurally rearranged by gut microbiota, yielding smaller and more polar metabolites like phenyl-γ-valerolactones, phenylvaleric acids and their conjugates. The present work i...