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GLP-1 Increases Circulating Leptin Levels in Truncal Vagotomized Rats

Morais, T; Pereira, SS; Andrade, S; Neves, D; Guimaraes, M; Nora, M; Carreira, MC; Casanueva, FF; Monteiro, MP

GLP-1 is a gastro-intestinal hormone acting within the gut/brain axis for energy balance regulation. We aimed to evaluate the role of the vagus nerve in whole-body energy homeostasis and in mediating GLP-1 effects. For this, rats submitted to truncal vagotomy and sham-operated controls underwent a comprehensive evaluation, including eating behavior, body weight, percentage of white (WAT) and brown adipose tissu...

Date: 2023   |   Origin: Repositório Aberto da Universidade do Porto
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