13 documents found, page 1 of 2
Book of Abstracts, International Symposium on Synthesis & Catalysis 2023
Marques, Carolina S.; Carreiro, Elisabete P.; Burke, Anthony J.On behalf of the Organizing Committee I am very pleased to welcome you to the fifth edition of the International Symposium on Synthesis and Catalysis (ISySyCat2023) once again at the historic University of Évora. The inaugural edition of this conference that took place in September 2015 (ISySyCat2015) was a great success and from that moment we have been building on this success, making this a regular biannual ...
Biosynthesis of silver-based nanoparticles: Critical assessment of antimicrobia...
Carrapiço, António; Pico, Manuel; Carreiro, Elisabete P.; Barrulas, Pedro; Mirão, José; Caldeira, Ana Teresa; Teixeira, Jorge; Dias, LuísSynthesis and application of nanoparticles (NPs) have shown promising results in various scientific fields due to their differentiating properties. However, current nanoparticle synthesis methods present environmental challenges. In this study biosynthesized silver nanoparticles (AgNPs) were produced from microbial culture supernatants as an alternative to traditional routes for controlling biodeteriogenic micr...
Chitosan Salts as Stabilizing Agents for the synthesis of Silver Nanoparticles ...
Carreiro, Elisabete P.; Teixeira, António P.S.; Costa, Marina; Burke, Anthony J.; Filho, Cesar; Gonçalves, Isabel; Craveiro, Alexandre; Silva, MaraIn this work, silver nanoparticles (AgNPs) were obtained by a chemical reduction method using different chitosan salts as stabilizing agents, able to protect and prevent against the aggregation of the nanoparticles. Various chitosan salts with different organic acids, which included: acetic, succinic, formic, propionic, malic, glycolic and lactic acid were used to form the chitosan salts. The use of these organ...
N-Substituted 3-Aminooxindoles and N-Propargyl Derivatives: Potential Biologica...
Hofmanova, Tereza; Marques, Carolina; García-Sosa, Alfonso T.; López, Óscar; Leitzbach, Luisa; Carreiro, Elisabete P.; González-Bakker, AdayMCIN/AEI/10.13039/501100011033; PID2021-123059OB-I00 and PID2020-116460RB-I00
Amino acids as chiral building blocks
Carreiro, Elisabete P.; Burke, AnthonyThis chapter is focused on the application of amino acids as building blocks in asymmetric synthesis. As a tool for accessing enantiopure compounds, amino acids have been used in four different ways, (i) as chiral precursors, (ii) as chiral reagents, (iii) as chiral auxiliaries, and (iv) as organocatalysts. For decades amino acids, particularly α-amino acids, have been used consistently for the synthesis of num...
N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregatio...
Marques, Carolina S.; López, Óscar; Bagetta, Donatella; Carreiro, Elisabete P.; Petralla, Sabrina; Bartolini, Manuela; Hoffmann, MatthiasOur goal was the evaluation of a series of N-1,2,3-triazole-isatin derivatives for multi-target activity which included cholinesterase (ChE) inhibition and β-amyloid (Aβ) peptide anti-aggregation. The compounds have shown considerable promise as butyrylcholinesterase (BuChE) inhibitors. Although the inhibition of eel acet- ylcholinesterase (eeAChE) was weak, the inhibitions against equine BuChE (eqBuChE) and hu...
Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural...
Brandão, Pedro; Marques, Carolina S.; Carreiro, Elisabete P.; Pineiro, Marta; Burke, Anthony J.Multicomponent reactions (MCRs) are a valuable tool in diversity-oriented synthesis. Its application to privileged structures is gaining relevance in the fields of organic and medicinal chemistry. Isatin, due to its unique reactivity, can undergo different MCRs, affording multiple interesting scaffolds, namely oxindole-derivatives (including spirooxindoles, bis-oxindoles and 3,3-disubstituted oxindoles) and eve...
Engaging Isatins in Multicomponent Reactions (MCRs) - Easy Access to Structural...
Brandão, Pedro; Marques, Carolina S.; Carreiro, Elisabete P.; Pineiro, Marta; Burke, Anthony J.Multicomponent reactions (MCRs) are a valuable tool in diversity-oriented synthesis. Its application to privileged structures is gaining relevance in the fields of organic and medicinal chemistry. Isatin, due to its unique reactivity, can undergo different MCRs, affording multiple interesting scaffolds, namely oxindole-derivatives (including spirooxindoles, bis-oxindoles and 3,3-disubstituted oxindoles) and eve...
A photoswitchable “host-guest¿? approach for the selective enrichment of dimeth...
Garcia, Raquel; Carreiro, Elisabete P.; Prates Ramalho, João P.; Burke, Anthony J.; Lima, João C.; Gomes da Silva, Marco D.R.; Costa Freitas, Ana MariaThis work describes the development of a new selective photocontrollable molecularly imprinted-based sorbent for the selective enrichment/pre-concentration of dimethoate from spiked olive oil samples. To achieve this goal an improved molecularly imprinted strategy relying on the embedding of a functional monomer containing an azobenzene chromophore as light-responsive element, on the crosslinked tridimensional ...
In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinester...
Bacalhau, Patrícia; Fernandes, Luís; Martins, M. Rosário; Candeias, Fátima; Carreiro, Elisabete P.; Caldeira, A.Teresa; Guedes, Rita C.From a screening study of various potential inhibitors for cholinesterases (ChEs), compound (rac)-1 (4-((3-hydroxy-2-oxo-3-phenylindolin-1-yl) methyl) piperidin-1-ium chloride) showed an IC50 of 18 μM for butyrylcholinesterase (BuChE). Herein we present a toxicological and pharmacological evaluation of (rac)-1 to determine its potential for use as an alternative ChE inhibitor for the treatment of Alzheimer’s di...