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Comparative pangenome analysis of capsulated Haemophilus influenzae serotype f ...

Gonzalez-Diaz, Aida; Carrera-Salinas, Anna; Pinto, Miguel; Cubero, Meritxell; van der Ende, Arie; Langereis, Jeroen D.; Domínguez, M. Ángeles

Haemophilus influenzae is an opportunistic pathogen adapted to the human respiratory tract. Non-typeable H. influenzae are highly heterogeneous, but few studies have analysed the genomic variability of capsulated strains. This study aims to examine the genetic diversity of 37 serotype f isolates from the Netherlands, Portugal, and Spain, and to compare all capsulated genomes available on public databases. Serot...


Detection of the Hmw adhesins in clinical Haemophilus influenzae isolates from ...

Bosh, Ana; González, Aida; Carrera-Salinas, Anna; Cubero, Meritxell; Marimón, José María; Bajanca-Lavado, Paula; Ardanuy, Carmen; Marti, Sara

Background: Non-typeable Haemophilus influenzae (NTHi) forms part of the normal nasopharyngeal microbiota in humans, but it is also an opportunistic pathogen causing respiratory infections and bacteraemia. Recently, high molecular weight (HMW1) proteins have been identified as a key factor for cell invasion, a feature implicated in persistence during chronic infection(a). Our aims were to identify the different...


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