3 documents found, page 1 of 1
The Dynamics of Interleukin-10-Afforded Protection during Dextran Sulfate Sodiu...
Cardoso, Ana; Castro, António G.; Martins, Ana Catarina; Carriche, Guilhermina M.; Murigneux, Valentine; Castro, Isabel; Cumano, Ana; Vieira, PauloInflammatory bowel disease encompasses a group of chronic-inflammatory conditions of the colon and small intestine. These conditions are characterized by exacerbated inflammation of the organ that greatly affects the quality of life of patients. Molecular mechanisms counteracting this hyperinflammatory status of the gut offer strategies for therapeutic intervention. Among these regulatory molecules is the anti-...
Interferon-ß regulates the production of IL-10 by toll-like receptor-activated ...
Silva, Diogo Pinto Lobo Jesus; Carriche, Guilhermina M.; Castro, António G.; Roque, Susana; Saraiva, MargaridaPattern recognition receptors, such as toll-like receptors (TLRs), perceive tissue alterations and initiate local innate immune responses. Microglia, the resident macrophages of the brain, encode TLRs which primary role is to protect the tissue integrity. However, deregulated activation of TLRs in microglia may lead to chronic neurodegeneration. This double role of microglial responses is often reported in immu...
Balancing the immune response in the brain: IL-10 and its regulation
Silva, Diogo Pinto Lobo Jesus; Carriche, Guilhermina M.; Saraiva, Margarida; Castro, António G.; Roque, SusanaBackground: The inflammatory response is critical to fight insults, such as pathogen invasion or tissue damage, but if not resolved often becomes detrimental to the host. A growing body of evidence places non-resolved inflammation at the core of various pathologies, from cancer to neurodegenerative diseases. It is therefore not surprising that the immune system has evolved several regulatory mechanisms to achie...