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Oncology in Mozambique: Overview of the Diagnostic, Treatment, and Research Cap...

Tulsidás, S; Fontes, F; Brandão, M; Lunet, N; Carrilho, C

Simple Summary Mozambique is one of the poorest countries in the world. Because of the limited number of human and material resources, priority is usually given to infectious diseases because they are the main cause of death in Mozambique. However, with the increasing adoption of an unhealthy lifestyle, the number of deaths attributed to cancer is also increasing. This review summarizes cancer incidence and mor...



Risk factors for oesophageal squamous cell carcinoma in Mozambique

Cunha, L; Fontes, F; Come, J; Lobo, V; Santos, LL; Lunet, N; Carrilho, C

Studies evaluating risk factors for the occurrence of oesophageal squamous cell carcinoma (ESCC) in high-risk regions might contribute to a better understanding of the oesophageal cancer aetiology and incidence variation worldwide. We aimed to quantify the association between alcohol, tobacco and dietary history, and the occurrence of ESCC in Mozambique. A case–control study was conducted at Maputo Central Hosp...


Impact of HIV infection on baseline characteristics and survival of women with ...

Brandão, M; Bruzzone, M; Franzoi, MA; de Angelis, C; Eiger, D; Caparica, R; Piccart-Gebhart, M; Buisseret, L; Ceppi, M; Dauby, N; Carrilho, C; Lunet, N

Background: As women living with HIV (WLWH) become older, their risk of developing breast cancer increases. Nonetheless, literature is conflicting regarding tumor stage, distribution of subtypes and overall survival among WLWH vs. HIV-negative women with breast cancer. We assessed differences in clinicopathological characteristics and overall survival between these two groups. Methods: Systematic review and met...


Comparing the cost of non-metastatic breast cancer care in a low-income vs a hi...

Brandão, M; Morais, S; Guisseve, A; Bata, G; Borges, M; Tulsidás, S; Pereira, S; Carrilho, C; Lunet, N

Breast cancer incidence is rising in low-income countries, but there is limited information regarding health resource allocation for its care. We assessed the cost of care during the first three years after diagnosis in a low-income country (Mozambique; n = 162 women) and compared it with a high-income country (Portugal, n = 703 women). Local currency prices were converted to 2019 international dollars (Int$). ...


Risk Factors for Breast Cancer, Overall and by Tumor Subtype, among Women from ...

Brandão, M; Guisseve, A; Damasceno, A; Bata, G; Silva-Matos, C; Alberto, M; Ferro, J; Garcia, C; Zaqueu, C; Lorenzoni, C; Leitão, D; Soares, O

Background: Breast cancer incidence is rising in Africa, but there are scare data regarding risk factors in this region. We assessed the relation between risk factors and the occurrence of breast cancer, overall and by tumor subtype in women from Mozambique. Methods: The associations between education, number of births, height, weight, body mass index (BMI), and breast cancer risk among 138 cases (participants ...


Survival Impact and Cost-Effectiveness of a Multidisciplinary Tumor Board for B...

Brandão, M; Guisseve, A; Bata, G; Firmino-Machado, J; Alberto, M; Ferro, J; Garcia, C; Zaqueu, C; Jamisse, A; Lorenzoni, C; Piccart-Gebhart, M

Background Despite the international endorsement of multidisciplinary tumor boards (MTBs) for breast cancer care, implementation is suboptimal worldwide, and evidence regarding their effectiveness in developing countries is lacking. We assessed the impact on survival and the cost-effectiveness of implementing an MTB in Mozambique, sub-Saharan Africa. Materials and Methods This prospective cohort study included ...


Breast cancer subtypes: implications for the treatment and survival of patients...

Brandão, M; Guisseve, A; Bata, G; Alberto, M; Ferro, J; Garcia, C; Zaqueu, C; Lorenzoni, C; Leitão, D; Come, J; Soares, O; Gudo-Morais, A; Schmitt, F

Background. Data regarding breast cancer epidemiology, treatment and survival in Africa are scarce. We aimed to assess the distribution of breast cancer subtypes in Mozambique and its impact on patients’ treatment and survival. The concordance of biomarker assessment between cytological and histological samples was also evaluated. Methods. Prospective cohort study including 210 patients diagnosed between Januar...


Hepatocellular carcinoma: Clinical-pathological features and HIV infection in M...

Cunha, L; Carrilho, C; Bhatt, N; Loforte, M; Maueia, C; Fernandes, F; Guisseve, A; Mbofana, F; Maibaze, F; Mondlane, L; Ismail, M; Dimande, L

Background and aims : Mozambique had been ranked among the countries with the highest global incidence of HCC with chronic hepatitis B infection and high exposure to aflatoxin-B1 (AFB1) being major risk factors. Indeed, HCC remains one of the most frequent cancer in Maputo. On the other hand, Mozambique has a high prevalence of infection with Human Immunodeficiency virus (HIV). Our study aims to describe the ep...


Fine needle aspiration cytology in Mozambique: Report of a 15-year experience

Carrilho, C; Ismail, M; Lorenzoni, C; Fernandes, F; Alberto, M; Akrami, K; Funzamo, C; Lunet, N; Schmitt, F

Background Fine needle aspiration cytology (FNAC) is an important diagnostic tool in a range of medical settings. It is fast, quick and a highly accurate diagnostic method and can be used, in settings with minimal laboratory infrastructures. Methods In this report, we describe the experience in the use of FNAC since it is introduction in 1996 in the Anatomical Pathology Service of the Maputo Central Hospital (M...


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