5 documents found, page 1 of 1
Butylone enantioseparation and ecotoxicity evaluation on Daphnia magna
Carvalho, A. R.; Morão, A. M.; Gonçalves, V. M. F.; Tiritan, M. E.; Lado, A. R.; Carrola, J. S.; Amorim, M. M.; Ribeiro, C.Background: The synthetic drug butylone (2-methylamino-1-(3,4-methylenedioxyphenyl)butan-1-one, BTL) is a chiral cathinone consumed in the form of racemate [1]. After consumption, BTL is metabolized and excreted along with its metabolites, and its residues are carried by sewerage systems to wastewater treatment plants (WWTPs) [2]. Both human metabolism and biodegradation in WWTPs may be enantioselective causing...
Effects of methylenedioxypyrovalerone (MDPV) in avoidance behaviour and reprodu...
Ribeiro, O.; Ferreira, J.; Sousa, J. R.; Natal-da-Luz, T.; Ribeiro, C.; Carrola, J. S.Background: The excessive use of psychoactive substances (PAS) is a global problem that directly and indirectly affects human, animal health and environment [1], related with “one health” concept. These substances and their metabolites enter in the wastewater through human excretion and consequently into water systems. The sewage sludge produced in wastewater treatment plants can be used as amendment in agricul...
Butylone effects on the behaviour of zebrafish (Danio rerio) larvae
Ribeiro, O.; Félix, L.; Ribeiro, C.; Carrola, J. S.Background: New psychoactive substances (NPS) represent an increasing human health and environmental concern. Despite the efforts to control their production and consumption, new molecules are identified every year. Consequently, their presence in water bodies has been reported raising concern due to potential negative impacts on non-target species such as fish [1], including the synthetic cathinone butylone (B...
Changes on swimming behavior induced by 3,4-methylenedioxypyrovalerone (MDPV) e...
Pérez-Pereira, A.; Carvalho, A.; Castro, B.; Carrola, J. S.; Fernandes, C.; Tiritan, M.; Ribeiro, C.Background: Synthetic cathinones (SC) are a group of novel illicit psychotropic substances that have been found in the aquatic environment at low concentrations [1] and nonetheless they can impact aquatic invertebrates [2]. SC can pose unwanted diverse adverse effects such as behavioral toxicity to non-target organisms [3]. The 3,4-methylenedioxypyrovalerone (MDPV) is a chiral SC with psychotropic properties si...
MDA effects on morphophysiology and reproduction of Daphnia magna – preliminary...
Morão, A. M.; Carvalho, A. R.; Couto, C.; Carrola, J. S.; Costa, P.; Castro, B.; Tiritan, M. E.; Ribeiro, C.Background: Psychoactive substances and their metabolites are considered emergent contaminants, raising environmental concerns due to the continuous input into aquatic ecosystems [1]. MDA (3,4-methylenedioxyamphetamine) is a pharmacologically active substance that represents the major metabolite of 3,4-methylenedioxymethamphetamine (MDMA); MDA may be present in MDMA preparations or occur as an illegal psychoact...