3 documents found, page 1 of 1
Exogenous surfactant prevents hyperoxiainduced lung injury in adult mice.
Bezerra, Frank Silva; Ramos, Camila de Oliveira; Castro, Thalles de Freitas; Araújo, Natália Pereira da Silva; Souza, Ana Beatriz Farias deBackground: In addition to the risk of developing ventilator-induced lung injury, patients with ARDS are at risk of developing hyperoxic injury due the supra-physiological oxygen supplementation clinically required to reverse hypoxemia. Alterations of endogenous surfactant system participate in the pulmonary dysfunction observed in ARDS. Administration of exogenous surfactant could have protective effects durin...
High-Fat diet increases HMGB1 expression and promotes lung inflammation in mice...
Souza, Ana Beatriz Farias de; Chírico, Máira Tereza Talma; Cartelle, Christiane Teixeira; Costa, Guilherme de Paula; Silva, André Talvani Pedrosa daThis study aims to evaluate the effects of a high-fat diet and mechanical ventilation on the pulmonary and systemic inflammatory response in C57BL/6 mice. Male C57BL/6 mice were divided into two groups: one received a standard diet, and the other received a high-fat diet. After 10 weeks, the groups were further divided into two groups each: control group (CG), mechanical ventilation group (MVG), diet group (DG)...
Enteric neuronal damage, intramuscular denervation and smooth muscle phenotype ...
Campos, Camila França; Cangussú, Silvia Dantas; Duz, Ana Luiza Cassin; Cartelle, Christiane Teixeira; Noviello, Maria de Lourdes; Veloso, Vanja MariaWe developed a novel murine model of long-term infection with Trypanosoma cruzi with the aim to elucidate the pathogenesis of megacolon and the associated adaptive and neuromuscular intestinal disorders. Our intent was to produce a chronic stage of the disease since the early treatment should avoid 100% mortality of untreated animals at acute phase. Treatment allowed animals to be kept infected and alive in ord...