41 documents found, page 1 of 5
Intestinal mucosal alterations parallel central demyelination and remyelination...
Ferreira, Carolina; Carvalho, Filipa; Vieira, Pedro; Alves, André; Palavra, Filipe; Almeida, Jani; Alves, Vera; Coscueta, EzequielBackground: The gut-brain axis has been increasingly recognized as a critical factor in Multiple Sclerosis (MS) pathophysiology. While its role in demyelination is well documented, gut-brain axis involvement during remyelination remains largely unexplored. Methods: Using the cuprizone (CPZ) model, which induces reversible demyelination and spontaneous remyelination upon toxin withdrawal, we investigated gut and...
Mitochondrial and Redox Changes in Periodontitis and Type 2 Diabetes Human Bloo...
Ferreira, Ildete L.; Costa, Solange; Moraes, Bruno; Costa, Ana; Fokt, Olga; Marinho, Daniela; Alves, Vera; Baptista, Isabel P.; Rego, A. CristinaPeriodontitis (PDT) and type 2 diabetes (T2D) have demonstrated a bidirectional relationship and imbalanced oxidative stress linked to mitochondrial dysfunction. Therefore, we investigated mitochondrial and redox (de)regulation in peripheral blood mononuclear cells (PBMCs) in comorbid T2D-PDT, compared to PDT, T2D patients, and control individuals. PBMCs were analyzed for mitochondrial respiration, reactive oxy...
Structure assignment of seized products containing cathinone derivatives using ...
Gonçalves, João; Alves, Vera; Aguiar, Joselin; Caldeira, Maria J.; Teixeira, Helena M.; Câmara, José S.The innovation of the new psychoactive substances (NPS) market requires the rapid identification of new substances that can be a risk to public health, in order to reduce the damage from their use. Twelve seized products suspected to contain illicit substances were analyzed by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), gas chromatography coupled to mass spectrometry (GC-MS)...
Type 2 and type 3 innate lymphoid cells at the maternal-fetal interface: implic...
Mendes, João; Rodrigues-Santos, Paulo; Areia, Ana Luísa; Almeida, Jani-Sofia; Alves, Vera; Santos-Rosa, Manuel; Mota-Pinto, AnabelaBackground Preterm birth (PTB) is one of the major causes of neonatal morbidity and mortality worldwide. It is commonly accepted that the act of giving birth is the final step in a proinflammatory signaling cascade, orchestrated by an intrauterine milieu coupled to hormonal cues. Consequently, the inflammatory process plays a pivotal role during the pathogenesis of human labor, both in term and preterm deliveri...
Qualitative data regarding the experiences of pregnant women with lupus in Brazil
Rodrigues, Larissa; Alves, Vera; Sim-Sim, Margarida; Surita, FernandaA qualitative design was performed as individual face-toface interviews with each participant, following a semistructured script based on open questions. Participants were interviewed at a specialized clinic, where, during prenatal care, women with stable systemic lupus erythematosus disease were received scheduled consultations. The sample was intentionally composed of women who attended a specialized high-ris...
Perceptions of women with systemic lupus erythematosus undergoing high-risk pre...
Rodrigues, Larissa; Alves, Vera; Sim-Sim, Margarida; Surita, FernandaBackground: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that often leads to situations of harm to the mother-fetus binomial. Given the potential for complications and morbidities in these pregnant women, it is essential that a multidisciplinary team be involved in pregnancy planning, as well as monitoring the course of the pregnancy and the postpartum period. Owing to the imminent ris...
Beer volatile fingerprinting at different brewing steps
Alves, Vera; Gonçalves, João; Figueira, José A.; Ornelas, Laura P.; Branco, Ricardo N.; Câmara, José S.; Pereira, Jorge A. M.Volatile fingerprints of a lager beer were carried out throughout five brewing steps to characterize the changes encompassing this process. Overall, 60 volatile organic metabolites (VOMs) were identified by headspace solid phase microextraction followed by gas chromatography mass spectrometry (HS-SPME/GC–MS). Specific profiles were observed at different brewing steps - aldehydes and furans dominate in wort, whe...
Opção estratégica como fator crítico de sucesso no turnaround de empresas em de...
Alves, VeraTurnaround são estratégias de contenção, que são adotadas por uma organização quando sente que a decisão tomada anteriormente está errada e que precisa de tomar medidas, antes que prejudique a lucratividade da empresa. Em Portugal, as empresas são maioritariamente constituídas por pequenas e médias empresas, sendo muito sensíveis ao mercado concorrencial cada vez mais forte. Quando entram já numa fase do seu ci...
NKT-Like (CD3+CD56+) Cells in Chronic Myeloid Leukemia Patients Treated With Ty...
Almeida, Jani Sofia; Couceiro, Patrícia; López-Sejas, Nelson; Alves, Vera; Růžičková, Lenka; Tarazona, Raquel; Solana, Rafael; Tavares, PauloTherapy with Tyrosine Kinase Inhibitors (TKI) aiming stable deep molecular response is the gold standard to treat Chronic Myeloid Leukemia (CML). NKT-like cells (CD3+CD56+) combine characteristics of T and NK cells. The physiopathological role of these cells remains unknown although the literature refers their association with inflammation, autoimmune diseases, and cancer. Since the information regarding the ro...
Current trends on microextraction by packed sorbent – fundamentals, application...
Pereira, Jorge A. M.; Gonçalves, João; Porto-Figueira, Priscilla; Figueira, José A.; Alves, Vera; Perestrelo, Rosa; Medina, Sonia; Câmara, José S.MEPS, the acronym of microextraction by packed sorbent, is a simple, fast and user- and environmen tally-friendly miniaturization of the popular solid-phase extraction technique (SPE). In fact, it has been widely shown that MEPS can easily replace SPE for most, if not all, previous applications. It can attain this with obvious gains in sample and solvent usage, which is greatly reduced without compromising the ...