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Analysis of Stereotyped B-Cell Receptor Frequencies Among Portuguese De Novo-Di...

Alves, Daniela; Ferreira, Gisela; Caldas, Joana; Fernandes, Mariana; Gaspar, Cátia; Alpoim, Mafalda; Carvalhais, Inês; Duarte, Sara; Silva, Helena

Background/objectives: Chronic lymphocytic leukemia (CLL) exhibits a heterogeneous clinical course influenced by genetic factors, such as the mutational status of immunoglobulin variable regions (IGHV). Recently, B-cell receptor (BcR) stereotypes have shown promising prognostic value, potentially surpassing IGHV status. The PAIS study analyzed BcR stereotypes and IGHV mutations in newly diagnosed Portuguese CLL...


Burnout and occupational stress in the medical residents of oncology, hematolog...

Joaquim, Ana; Custódio, Sandra; Savva-Bordalo, Joana; Chacim, Sérgio; Carvalhais, Inês; Lombo, Liliana; Lopes, Heitor; Araújo, António; Gomes, A. Rui

Burnout is a professional syndrome associated with stress caused by overwork. Our aim was to calculate the prevalence of burnout and stress on medical residents of Oncology, Haematology and Radiotherapy in Portugal, as well as to determine predictors of burnout and stress. An anonymous questionnaire was applied (n = 118). Statistical analysis consisted of a descriptive and inferential analysis. The prevalence o...


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