16 documents found, page 1 of 2
Practical and Multidisciplinary Review on Wilson Disease: The Portuguese Perspe...
Calinas, Filipe; Cardoso, Hélder; Carvalhana, Sofia; Ferreira, José; Gonçalves, Cristina; Magalhães, Marina; Miranda, Helena Pessegueiro; Presa, JoséWilson disease (WD) is a genetic disorder of copper metabolism caused by mutations in the ATP7B gene resulting in toxic copper accumulation in several organs. WD can manifest as liver disease, a progressive neurological disorder, a psychiatric illness, or a combination of these. Other clinical manifestations can also occur. Diagnosis is challenging and typically requires a range of biochemical tests, imaging, g...
Effect of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, ...
Cespiati, Annalisa; Rodrigues, Inês Coelho; Santos, Inês; Policarpo, Sara; Carvalhana, Sofia; Fracanzani, Anna Ludovica; Cortez-Pinto, HelenaBackground and Aims The beneficial effect of Hepatitis C virus (HCV) eradication by direct antiviral agents (DAAs) on liver fibrosis is well defined. Despite this, the impact of viral eradication in both hepatic and extra-hepatic metabolic features is underreached. This systematic review aimed to synthesize the evidence on the impact of HCV eradication by DAAs on liver steatosis, carotid atherosclerosis, glucid...
Cirrhosis is associated with lower serological responses to COVID-19 vaccines i...
Simão, André; Palma, Carolina; Izquierdo-Sanchez, Laura; Putignano, Antonella; Carvalho-Gomes, Angela; Posch, Andreas; Zanaga, Paola; Girleanu, IrinaBackground & aims: The response of patients with chronic liver disease (CLD) to COVID-19 vaccines remains unclear. Our aim was to assess the humoral immune response and efficacy of two-dose COVID-19 vaccines among patients with CLD of different aetiologies and disease stages. Methods: A total of 357 patients were recruited in clinical centres from six European countries, and 132 healthy volunteers served as con...
Influence of COVID-19 on patients with esophageal varices under prophylactic en...
Craciun, Ana; Botto, Inês; Lopes, Joao; Moura, Miguel; Carvalhana, Sofia; Cortez-Pinto, Helena; Marinho, RuiBackground and objectives: Endoscopic band ligation (EBL) plays a critical role in patients with clinically significant portal hypertension, as variceal eradication (VE) is essential to prevent further variceal upper gastrointestinal bleeding (GI). The emergence of COVID-19 has led to a dramatic reduction in endoscopic activity. Our study aimed to evaluate the effect of COVID-19 on VE, GI, and 6-month mortality...
Clinical, histological and molecular profiling of different stages of alcohol-r...
Ventura-Cots, Meritxell; Argemi, Josepmaria; Jones, Patricia D; Lackner, Carolin; El Hag, Mohamed; Abraldes, Juan G; Alvarado, Edilmar; Clemente, AnaObjective: Alcohol-related liver disease (ALD) ranges from never-decompensated ALD (ndALD) to the life-threatening decompensated phenotype, known as alcohol-related hepatitis (AH). A multidimensional study of the clinical, histological and molecular features of these subtypes is lacking. Design: Two large cohorts of patients were recruited in an international, observational multicentre study: a retrospective co...
Severe acute autoimmune hepatitis: how to early predict who will not respond to...
João, Mafalda; Carvalhana, Sofia; Moura, Miguel; Freitas, Luís Carlos; Silva, Andrea; Figueiredo, Pedro; Liberal, Rodrigo; Macedo, GuilhermeBackround: In acute severe autoimmune hepatitis (AS-AIH), the early identification of predictors of non-response to corticosteroids and the optimal timing for liver transplantation (LT) remains controversial. Aims: To determine early predictors of non-response to corticosteroids and to assess the usefulness of severity scores, namely the recently developed SURFASA. Methods: Retrospective multicentre cohort stud...
Do MAFLD patients with harmful alcohol consumption have a different dietary int...
Policarpo, Sara; Carvalhana, Sofia; Craciun, Ana; Crespo, Ricardo Rios; Cortez-Pinto, HelenaThe term metabolic-associated fatty liver disease (MAFLD) has been proposed to define positively fatty liver disease in the form associated with metabolic risk factors. The aim of this study was to assess the dietary intake of MAFLD and explore a possible relationship between its inflammatory characteristics (assessed by Dietary Inflammatory Index-DII®), the degree of liver fibrosis (assessed by transient elast...
Prevalence and risk factors of fatty liver in Portuguese adults
Leitão, Jorge; Carvalhana, Sofia; Cochicho, Joana; Silva, Ana Paula; Velasco, Francisco; Medeiros, Isabel; Alves, Ana Catarina; Bourbon, MafaldaBackground: Prevalence of fatty liver (FL) and nonalcoholic fatty liver disease (NAFLD) depends mainly on obesity, diabetes and genetic factors. FL and NAFLD prevalence was evaluated in Portuguese adult population and correlated with several risk factors and related mortality data, within the same period. Materials and methods: A cross-sectional, population-based multicenter study, voluntary and randomly select...
Prevalence and risk factors of fatty liver in Portuguese adults
Leitão, Jorge; Carvalhana, Sofia; Cochicho, Joana; Silva, Ana Paula; Velasco, Francisco; Medeiros, Isabel; Alves, Ana Catarina; Bourbon, MafaldaBackground: Prevalence of fatty liver (FL) and nonalcoholic fatty liver disease (NAFLD) depends mainly on obesity, diabetes and genetic factors. FL and NAFLD prevalence was evaluated in Portuguese adult population and correlated with several risk factors and related mortality data, within the same period. Materials and methods: A cross-sectional, population-based multicenter study, voluntary and randomly select...
No Evidence for Lower Levels of Serum Vitamin D in the Presence of Hepatic Stea...
Leitão, Jorge; Carvalhana, Sofia; Silva, Ana Paula; Velasco, Francisco; Medeiros, Isabel; Alves, Ana Catarina; Bourbon, Mafalda; Oliveiros, BárbaraIntroduction and aims: Nonalcoholic fatty liver disease (NAFLD) has become highly prevalent, paralleling the pandemic of obesity and diabetes, and represents an important burden. Nutrition knowledge is fundamental, in prevention, evolution and treatment of NAFLD. Association of low serum levels of vitamin D (VD) with several diseases, including NAFLD, has been emphasized in the last decade. We evaluated how ser...