2 documents found, page 1 of 1
Prevalence of Vitamin D Deficiency and its Predictors in the Portuguese Populat...
Duarte, C; Carvalheiro, H; Rodrigues, A; Dias, S; Marques, A; Santiago, T; Canhão, H; Branco, J; Pereira da Silva, JAVitamin D deficiency is prevalent worldwide, but its prevalence is unknown in adult Portuguese population. In Portugal, 66% of adults present Vitamin D insufficiency/deficiency. Winter, living in Azores, older age, and obesity were the most important risk factors. It highlights the need of strategies to prevent vitamin D deficiency in Portugal. Objective: To estimate the prevalence and risk factors of vitamin D...
Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse mod...
Raposo, BR; Rodrigues-Santos, P; Carvalheiro, H; Água-Doce, AM; Carvalho, L; Pereira da Silva, JA; Graça, L; Souto-Carneiro, MMOBJECTIVE: CD8+ T cells are part of the T cell pool infiltrating the synovium in rheumatoid arthritis (RA). However, their role in the pathogenesis of RA has not been fully delineated. Using the K/BxN mouse model of spontaneous chronic arthritis, which shares many similarities with RA, we studied the potential of CD8+ T cell depletion with monoclonal antibodies (mAb) to stop and reverse the progression of exper...