4 documents found, page 1 of 1
Prevalence of vitamin D deficiency and its predictors in the Portuguese populat...
Duarte, Catia; Carvalheiro, Helena; Rodrigues, Ana M.; Dias, Sara S.; Marques, Andréa; Santiago, Tânia; Canhão, Helena; Branco, Jaime CunhaSummary Vitamin D deficiency is prevalent worldwide, but its prevalence is unknown in adult Portuguese population. In Portugal, 66% of adults present Vitamin D insufficiency/deficiency. Winter, living in Azores, older age, and obesity were the most important risk factors. It highlights the need of strategies to prevent vitamin D deficiency in Portugal. Objective To estimate the prevalence and risk factors of vi...
Deficient production of reactive oxygen species leads to severe chronic DSS-ind...
Rodrigues-Sousa, Tiago; Ladeirinha, Ana Filipa Ferreira; Santiago, Ana Raquel; Carvalheiro, Helena; Raposo, Bruno; Alarcão, Ana; Cabrita, AntónioBackground: Colitis is a common clinical complication in chronic granulomatous disease (CGD), a primary immunodeficiency caused by impaired oxidative burst. Existing experimental data from NADPH-oxidase knockout mice propose contradictory roles for the involvement of reactive oxygen species in colitis chronicity and severity. Since genetically controlled mice with a point-mutation in the Ncf1 gene are susceptib...
CD8+T cell profiles in patients with rheumatoid arthritis and their relationshi...
Carvalheiro, Helena; Duarte, Cátia; Silva-Cardoso, Sandra; Silva, José A. P. da; Souto-Carneiro, M. MargaridaObjective CD8+T cells are abundant in rheumatoid arthritis (RA). However, their role in the disease pathogenesis is poorly defined. Here we investigated the relationship between disease activity and CD8+T cell phenotypes, production of cytokines and cytotoxic molecules in RA peripheral blood (PB) and synovial fluid (SF). Methods CD8+T cell phenotypes were determined in 96 patients with RA (44 in remission, 34 w...
Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse mod...
Raposo, Bruno R.; Rodrigues-Santos, Paulo; Carvalheiro, Helena; Água-Doce, Ana M.; Carvalho, Lina; Pereira da Silva, José A.; Graça, LuísObjective. CD8+ T cells are part of the T cell pool infiltrating the synovium in rheumatoid arthritis (RA). However, their role in the pathogenesis of RA has not been fully delineated. Using the K/BxN mouse model of spontaneous chronic arthritis, which shares many similarities with RA, we studied the potential of CD8 T cell depletion with monoclonal antibodies (mAb) to stop and reverse the progression of experi...