35 documents found, page 1 of 4
Antagonist G-targeted liposomes for improved delivery of anticancer drugs in sm...
Carvalheiro, Manuela; Ferreira-Silva, Margarida; Holovanchuk, Denys; Marinho, H. Susana; Moreira, João Nuno; Soares, Helena; Corvo, M. LuisaLigand-mediated targeted liposomes have the potential to increase the therapeutic efficacy of anticancer drugs. This work aimed to evaluate the ability of antagonist G, a peptide targeting agent capable of blocking the action of multiple neuropeptides, to selectivity improve targeting and internalization of liposomal formulations (long-circulating liposomes, LCL, and stabilized antisense lipid particles contain...
Sustainable valorization of food-processing industry by-products: challenges an...
Simões, Sandra; Costa, Ana; Faria-Silva, Ana Catarina; Ascenso, Andreia; Marto, Joana; Carvalheiro, Manuela; Gonçalves, Lídia; Marques, M.; Paiva, A.The food-processing industry generates large quantities of residues, which may represent sustainable and rich sources of bioactive compounds. The extraction of bioactives from industrial residues could be a good alternative for the valorization of this by-product with recognized biological actions. Conventional extraction methods consume large volumes of organic solvents, which are expensive, toxic, and hazardo...
Novel Antiretroviral Therapeutic Strategies for HIV.
Cunha, Rita F.; Simões, Sandra; Carvalheiro, Manuela; Azevedo-Pereira, José Miguel; Santos-Costa, Quirina; Ascenso, AndreiaWhen the first cases of HIV infection appeared in the 1980s, AIDS was a deadly disease without any therapeutic alternatives. Currently, there is still no cure for most cases mainly due to the multiple tissues that act as a reservoir for this virus besides the high viral mutagenesis that leads to an antiretroviral drug resistance. Throughout the years, multiple drugs with specific mechanisms of action on distinc...
Synchronous insight of in vitro and in vivo biological activities of Sambucus n...
Mota, Ana Henriques; Andrade, Joana M.; Rodrigues, Maria Joao; Custódio, Luísa; Bronze, Maria Rosario; Duarte, Noelia; Baby, Andre; Rocha, JoaoThere is a re-emerging interest in natural products as reputable sources of new active pharmaceutical ingredients. This study synchronously reports in vitro, with more than one cell line, and in vivo biological activities of extracts obtained from Sambucus nigra. Using several solvents and techniques, eighteen extracts were obtained from fresh and dried berries, and fresh flowers. The flavonoid content and iden...
Exploratory factor study of adherence behavioral dimensions in diabetes mellitu...
Massano-Cardoso, Ilda Maria; Daniel, Fernanda Bento; Rodrigues, Vitor; Carvalheiro, ManuelaBackground & Aim: The current study sought out to conduct an exploratory factor analysis in order to examine behavioral dimensions associated with adherence in diabetes mellitus (DM) patients. Additionally, our goal was to test a theoretical model consisting of internal and relational factors. Method: Three hundred and forty-seven patients attending consultations at the Serviço de Endocrinologia, Diabe...
Multifunctional gold-nanoparticles: A nanovectorization tool for the targeted d...
Fernandes, Alexandra; Jesus, João; Martins, Pedro; Figueiredo, Sara; Rosa, Daniela; Martins, Luisa; Corvo, M. Luísa; Carvalheiro, ManuelaDue to their small size and unique properties, multifunctional nanoparticles arise as versatile delivery systems easily grafted with a vast array of functional moieties, such as anticancer cytotoxic chemotherapeutics and targeting agents. Here, we formulated a multifunctional gold-nanoparticle (AuNP) system composed of a monoclonal antibody against epidermal growth factor receptor (EGFR) (anti-EGFR D-11) for ac...
Estudo fatorial exploratório das dimensões comportamentais de adesão em pessoas...
Massano-Cardoso, Ilda; Daniel, Fernanda; Rodrigues, Vítor; Carvalheiro, ManuelaObjetivos: Analisar as dimensões comportamentais associadas à adesão em pessoas com diabetes mellitus (DM). Testar o modelo teórico composto por fatores internos e relacionais ao paciente tendo por base oito instrumentos de autorresposta. Métodos: 347 doentes a frequentar consultas de diabetes do Serviço de Endocrinologia, Diabetes e Metabolismo no Centro Hospitalar e Universitário de Coimbra e na Associação Po...
Estudo Fatorial Exploratório das Dimensões Comportamentais de Adesão em Pessoas...
Massano-Cardoso, Ilda; Daniel, Fernanda; Rodrigues, Vitor; Carvalheiro, ManuelaObjetivos: Analisar as dimensões comportamentais associadas à adesão em pessoas com diabetes mellitus (DM). Testar o modelo teórico composto por fatores internos e relacionais ao paciente tendo por base oito instrumentos de autorresposta. Métodos: 347 doentes a frequentar consultas de diabetes do Serviço de Endocrinologia, Diabetes e Metabolismo no Centro Hospitalar e Universitário de Coimbra e na Associação Po...
Agonistas e antagonistas dos recetores 5-HT1A e 5-HT2A no tratamento do cancro ...
Menezes, Ana Catarina; Oliveira, José Miguel; Carvalheiro, Manuela; Oliveira, Helena; Ascenso, AndreiaA exposição à radiação UV é a principal causa do aparecimento de cancro da pele, um processo no qual a serotonina (5-HT) está intimamente envolvida. Este projeto foca-se no potencial dos recetores da serotonina, nomeadamente os 5-HT1/2A, enquanto alvos terapêuticos para o controlo do cancro da pele do tipo melanoma. [...]
TERT promoter mutations are a major indicator of poor outcome in differentiated...
Melo, Miguel; Gaspar Da Rocha, Adriana; Vinagre, João; Batista, Rui; Peixoto, Joana; Tavares, Catarina; Celestino, Ricardo; Almeida, AnaContext: Telomerase promoter mutations (TERT) were recently described in follicular cell-derived thyroid carcinomas (FCDTC) and seem to be more prevalent in aggressive cancers. Objectives: We aimed to evaluate the frequency of TERT promoter mutations in thyroid lesions and to investigate the prognostic significance of such mutations in a large cohort of patients with differentiated thyroid carcinomas (DTCs). De...