89 documents found, page 1 of 9
Practical Guidance on the Detection of NTRK Fusions in Sarcomas: Current Status...
Fernandes, I; Macedo, D; Gouveia, E; Ferreira, A; Lima, J; Lopez, D; Melo-Alvim, C; Carvalho, A; Tavares, P; Rodrigues-Santos, P; Cardoso, PSarcomas are a rare and heterogeneous group of mesenchymal malignant tumors and account for approximately 1% of all adult cancers and around 20% of all pediatric solid tumors in Europe. Technology advances have enabled a more accurate and efficient characterization of the molecular mechanisms underlying the pathogenesis of sarcoma subtypes and revealed novel and unexpected therapeutic targets with prognostic/pr...
Polymorphisms and haplotypes of TOLLIP and MUC5B are associated with susceptibi...
Mota, PC; Soares, ML; Ferreira, AC; Santos, RF; Cavaleiro Rufo, J; Vasconcelos, D; Carvalho, A; Guimarães, S; Vasques-Nóvoa, F; Cardoso, C; Melo, NIntroduction and Objectives: Hypersensitivity pneumonitis (HP) is an interstitial lung disease with diverse clinical features that can present a fibrotic phenotype similar to idiopathic pulmonary fibrosis (IPF) in genetically predisposed individuals. While several single nucleotide polymorphisms (SNPs) have been associated with IPF, the genetic factors contributing to fibrotic HP (fHP) remain poorly understood....
Treatment patterns and preferences of people living with HIV starting or switch...
Pedro, L; Zagalo, A; Tavares, R; Pacheco, P; Oliveira, J; Vaz Pinto, I; Serrão, R; Tavares, S; Brito, P; Maltez, F; Neves, I; Carvalho, A; Teófilo, EBackground: There is a lack of up-to-date real-life evidence on antiretroviral therapy (ART) strategies among people living with HIV (PLWH) in Portugal. This study aimed to describe the treatment strategy used in PLWH either initiating or switching ART. Methods: Non-interventional, cross-sectional, multicenter study carried out between December 2019 and October 2021 in Portugal. Results: A total of 237 PLWH wer...
Kawasaki Disease: A Rare Case of a Non-pediatric Patient
Ramos, M; Seguro Paula, F; Carvalho, A; Pinheiro, M; Ramos, AKawasaki disease (KD) is an inflammatory condition more common in children but rare in adults, where diagnosis can be challenging due to nonspecific symptoms. Early recognition is essential to prevent severe complications. We present the case of a 26-year-old male with adult-onset KD who initially presented with vague symptoms, resulting in diagnostic delays. The condition progressed to life-threatening cardiov...
The impact of methylene blue in colon cancer: a retrospective multicentric study
Carvalho, A; Limbert, M; Cabral, F; Fareleira, A; Duarte, A; Barroca, R; Goulart, A; Leão, PIntroduction: Discussions about the optimal lymph node (LN) count and its therapeutic consequences have persisted over time. The final LN count in colorectal tissues is affected by a variety of variables (patient, tumor, operation, pathologist, immune response). Methylene blue (MB) intra-arterial injection is a simple and inexpensive procedure that can be used to enhance lymph node count. Aim: Analyze whether t...
Vancomycin-Loaded, Nanohydroxyapatite-Based Scaffold for Osteomyelitis Treatmen...
Alegrete, N; Sousa, SR; Padrão, T; Carvalho, A; Lucas, R; Canadas, RF; Lavrador, C; Alexandre, N; Gärtner, F; Monteiro, FJ; Gutierres, MThe treatment for osteomyelitis consists of surgical debridement, filling of the dead space, soft tissue coverage, and intravenous administration of antimicrobial (AM) agents for long periods. Biomaterials for local delivery of AM agents, while providing controllable antibiotic release rates and simultaneously acting as a bone scaffold, may be a valuable alternative; thus, avoiding systemic AM side effects. V-H...
Inflammatory Myofibroblastic Tumour of the Common Bile Duct
Almeida e Sousa, M; Carvalho, A; Mega, R; Bilhim, TInflammatory myofibroblastic tumour is a rare entity of indeterminate biological potential with a reduced tendency for recurrence and metastasis. Although it can arise from multiple organs, the bile duct is a very rare site of origin. We report the case of a 75-year-old asymptomatic male with elevated gamma-glutamyl transferase [1575 U/L (12 - 64 U/L)] and alkaline phosphatase [271 U/L (40 - 150 U/L)]. Computed...
Foundations and trends of high resolution energy dispersive PIXE (HiRED-PIXE)
Reis, Miguel; Carvalho, A; Taborda, A; Chaves, PA; Conceição, Patrícia; Madureira, PedroHigh Resolution Particle Induced X-ray Emission, for short HR-PIXE, dates back to 1977 and is, therefore, nearly as old as standard PIXE itself. Until roughly ten years ago, High Resolution PIXE (HR-PIXE) work used only wavelength dispersive spectrometers (WDS). The installation, in 2008, of an X-ray Microcalorimeter Spectrometer, XMS at CTN (ITN at the time) 3MV tandetron, altered this situation and, as can be...
Nationwide Access to Endovascular Treatment for Acute Ischemic Stroke in Portugal
Carvalho Dias, M; Soares dos Reis, R; Santos, JV; Paiva Nunes, A; Ferreira, P; Maia, B; Fragata, I; Reis, J; Ramos Lopes, J; Cruz, L; Santo, GIntroduction: Since the publication of endovascular treatment trials and European Stroke Guidelines, Portugal has re-organized stroke healthcare. The nine centers performing endovascular treatment are not equally distributed within the country, which may lead to differential access to endovascular treatment. Our main aim was to perform a descriptive analysis of the main treatment metrics regarding endovascular ...
Pulmonary Emphysema Regional Distribution and Extent Assessed by Chest Computed...
Gomes, P; Bastos, HN; Carvalho, A; Lobo, A; Guimarães, A; Rodrigues, RS; Zin, WA; Carvalho, ARSObjective: This study aimed to evaluate how emphysema extent and its regional distribution quantified by chest CT are associated with clinical and functional severity in patients with chronic obstructive pulmonary disease (COPD). Methods/Design: Patients with a post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) < 0.70, without any other obstructive airway disease, who ...