26 documents found, page 1 of 3
Development of a predictive model of financial performance indicators for organ...
Freitas, Fábio Rafael Santos de; Domingues, José Pedro Teixeira; Costa, Lino; Carvalho, A. M.Purpose - Artificial neural networks (ANN) are efficient in dealing with complex problems, therefore, its use for the development of prediction methods of key performance indicators (KPI) can prove as a source of competitive advantage for companies. The objective of this work was to evaluate the use of ANN to perform financial KPI forecasts in companies that use Integrated Management Systems. Design/methodology...
Supply chain quality management and industry 5.0 - a literature review and anal...
Lazzaris, Joana; Carvalho, A. M.; Carvalho, Maria SameiroThere is a growing interest in the concept of industry 5.0 (i5.0), towards a more sustainable, resilient and human-oriented industry, as its development is seen as one of the means to achieve the EU2030 goals. To pursue the objectives of i5.0 it is crucial to measure relevant indicators through regenerative metrics and frameworks. However, there is a gap in understanding how Supply Chain Quality Management (SCQ...
Hyaluronan brush-like copolymers promote CD44 declustering in breast cancer cells
Carvalho, A. M.; Valcarcel, J.; Costa, Diana Pereira Soares; Gomes, M.; Vázquez, J. A.; Reis, R. L.; Novoa-Carballal, Ramon; Pashkuleva, I.We report on the synthesis of hyaluronan (HA) brush-like copolymers and their application as antagonists of tumorigenic CD44-HA interactions. HA (4.8 kDa, ca. 24 saccharides) was grafted on 2-hydrohyethyl methacrylate (HEMA) by end-on oxime ligation. The obtained copolymers were compared with low and high molecular weight HA in terms of hydrolysis kinetics in the presence of hyaluronidase (isothermal titration ...
The mediating role of organizational culture in managing the relationship betwe...
Heringer, R.; Carvalho, A. M.; Sampaio, PauloQuality and Innovation play a fundamental role in helping organizations secure sustainable competitive advantage. However, the nature of their relationship has seen contradictory results. This ongoing research project seeks to relaunch the debate on the relationship between TQM and Innovation, doing so from a novel perspective that considers the cultural orientation of an organization as the key success factor ...
On agile metrics for operations management: measuring and aligning agility with...
Carvalho, A. M.; Sampaio, Paulo; Rebentisch, E.High-quality performance in Operations Management has been measured through different Excellence frameworks, with special emphasis on Operational Excellence models. By allowing to track performance indicators, identify improvement opportunities, and tackle operational limitations, such frameworks have proven their validity throughout the years. However, and despite their history of success, these frameworks rem...
Gomphrena globosa L. como fonte de corantes naturais: caracterização em betacia...
Roriz, C. Lobo; Barros, L.; Carvalho, A. M.; Santos-Buelga, C.; Ferreira, I. C.F.R.No presente trabalho, descreve-se a composição em betacianidinas (classe das betalaínas com pigmentação vermelha-roxo) da perpétua roxa (Gomphrena globosa L.), de forma a destacar esta planta como fonte alternativa de corantes naturais. A análise foi feita por cromatografia líquida de alta eficiência acoplada a um detetor de fotodíodos e espetrometria de massa com ionização por dispersão de eletrões (HPLC-PDA-M...
Evaluation of the potential of collagen from codfish skin as a biomaterial for ...
Carvalho, A. M.; Marques, A. P.; Silva, Tiago José Quinteiros Lopes Henriques; Reis, R. L.Collagen is one of the most widely used biomaterials, not only due its biocompatibility, biodegradability and weak antigenic potential, but also due to its role in the structure and function of tissues. Searching for alternative collagen sources, the aim of this study was to extract collagen from the skin of codfish, previously obtained as a by-product of fish industrial plants, and characterize it regarding it...
Redox-responsive micellar nanoparticles from glycosaminoglycans for CD44 target...
Carvalho, A. M.; Teixeira, R.; Novoa-Carballal, R.; Pires, R. A.; Reis, R. L.; Pashkuleva, I.Cancer progression is associated with overexpression of various receptors at the cell surface. Among these, CD44 is known to recognize and bind specifically hyaluronan (HA) and interact with less affinity to other glycosaminoglycans (GAGs), such as chondroitin sulfate (CS). In this study, we describe a simple method to obtain micellar nanoparticles with a GAG shell (HA or CS) as potential drug delivery systems ...
Operational excellence as a means to achieve an enduring capacity to change – r...
Carvalho, A. M.; Sampaio, P.; Rebentisch, E.; Saraiva, P.The efforts to develop a visual framework that depicted the relationships between the concepts of operational excellence, organizational culture and organizational agility concluded with the development of an early conceptual model depicting each concept, their enablers, the links between them and their results. However, as research advanced and theory and discussion cumulated, doubts were generated over the ca...
Leis de atenuação sísmica para portugal Continental considerando o tipo de terr...
Carvalho, A. M.; Gomes, R.; Rodrigues, J.; Delfim, R.O presente trabalho tem como objectivo a dedução de leis de atenuação sísmica para Portugal Continental, considerando o tipo de terreno. A avaliação da resposta sísmica do terreno foi realizada com uma abordagem estatística baseada na teoria dos processos estocásticos, assumindo-se um modelo unidimensional correspondente á propagação vertical de ondas S incidindo na direção vertical e através de um semi-espaço ...