8 documents found, page 1 of 1
Conhecimento sobre uso de medicamentos potencialmente perigosos entre enfermeir...
Santos, Gilvan Oliveira dos; Farre, Anny Giselly Milhome da Costa; Santana, Ingrede Tatiane Serafim; Rocha, Hertaline Menezes do NascimentoObjective: to characterize the knowledge about the use of potentially dangerous drugs among hospital health care nurses. Methods: quantitative, descriptive-exploratory re-search, with the application of a validated questionnaire, translated and adapted in Brazil, on potentially dangerous medications, with 26 nursing assistants in a university hos-pital. Univariate and bivariate descriptive statistical analysis ...
Evaluation of the cytotoxicity of structurally correlated p-menthane derivatives
Andrade, Luciana Nalone; Lima, Tamires Cardoso; Amaral, Ricardo Guimarães; Pessoa, Cláudia do Ó; Moraes Filho, Manoel Odorico de; Soares, Bruno MarquesCompounds isolated from essential oils play an important role in the prevention and treatment of cancer. Monoterpenes are natural products, and the principal constituents of many essential oils. The aim of this study was to investigate the cytotoxic potential of p-menthane derivatives. Additionally, analogues of perillyl alcohol, a monoterpene with known anticancer activity, were evaluated to identify the molec...
In vivo antitumoural activity and composition of an oil extract of Brazilian pr...
Carvalho, Adriana Andrade; Finger, Daiane; Machado, Christiane Schinieder; Schmid, Eduardo Morgado; Costa, Patrícia Marçal daThe present study aimed to evaluate in vivo and in vitro the antitumoural activity of a propolis extract obtained with edible vegetable oil and its fractions and also to investigate its chemical composition by LC–MS and LC–MS/MS. To evaluate the toxicological aspects related to the propolis extract treatment, hematological, biochemical, histopathological and morphological analyses of treated animals were per- f...
Cardiovascular effects of Hyptis fruticosa essential oil in rats
Santos, Márcio Roberto Viana; Carvalho, Adriana Andrade; Medeiros, Isac A.; Alves, Péricles Barreto; Marchioro, Murilo; Antoniolli, Angelo RobertoIn non-anesthetized normotensive rats, Hyptis fruticosa essential oil (HFEO, 5, 10, 20 and 40 mg/kg; i.v.) induced hypotension associated with tachycardia. In intact and isolated rings of rat superior mesenteric artery (control), HFEO (1 – 1000 μ g/ml, n =6, cumulatively) induced concentration-dependent relaxations of tonus induced by 10 μ M phenylephrine (Phe) (pD 2 =2.6±0.27; E max =64±8.3%). In denuded endot...
Inhibition of metastatic potential of B16-F10 melanoma cell line in vivo and in...
Carvalho, Adriana Andrade; Costa, Patrícia Marçal da; Souza, Luciana Gregório da Silva; Lemos, Telma Leda Gomes de; Alves, Ana Paula Negreiros NunesAim: The aim of this study was to determine the antimetastatic potential of bi fl orin using in vivo and in vitro approaches. Main methods: Bi fl orin was isolated from Capraria bi fl ora collected in Fortaleza, Ceará, Brazil. Adhesion, migra- tion and invasion assays were performed to avail of the antimetastatic potential of this quinone. Experimen- tal metastasis was performed to avail of the antimetastatic p...
Cardiovascular effects and acute toxicity of the aqueous extract of Costus spic...
Menezes, Igor Alexandre Côrtes; Carvalho, Adriana Andrade; Antoniolli, Angelo Roberto; Santos, Márcio Roberto VianaCardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (AECS) were studied in rats and mice. In non anaesthetized normotensive rats (n = 6), AECS (0.5, 1.0, 5.0 and 10.0 mg/kg; i.v., randomly) induced hypotension associated with tachycardia. In intact or endothelium-denuded rings of rat superior mesenteric artery, AECS (0.1 - 100.0 μ g/ mL, n = 4) provoked relaxation of the t...
Estudo da atividade antimetastática da biflorina, uma o-naftoquinona isolada da...
Carvalho, Adriana AndradeThe main cause of mortality in cancer patients is related to the incidence of secondary tumors in the body. Owning up to the deficiency of therapeutic schemes direct to the treatment of metastasis, many efforts are being launched to develop drugs with anti-metastatic potential. In previous studies performed in our laboratory, biflorin, an o-naphthoquinone isolated from the roots of Capraria biflora, was found t...
Estudo do potencial antimetastático da biflorina
Carvalho, Adriana AndradeMetastasis remains the leading cause of death from cancer. Due to the absence of pharmacological therapy for the treatment of secondary tumors, the search for new drugs with antimetastatic potential is important to the development of new anticancer drugs. In this context we decided to evaluate the antimetastatic potential of biflorin, an o-naphthoquinone isolated from roots of Capraria biflora. In cell prolifer...