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Involvement of intrinsic mitochondrial pathway in neosergeolide-induced apoptos...
Coelho Cavalcanti, Bruno; Costa, Patrícia Marçal da; Carvalho, Adriana Andrade Carvalho; Rodrigues, Francisco Augusto Rocha Santos; Amorim, Rodrigo C.N.Context: Quassinoids are biologically active secondary metabolites found exclusively in the Simaroubaceae family of plants. These compounds generally present important biological properties, including cytotoxic and antitumor properties. Objective: In the present study, the cytotoxic effects of neosergeolide, a quassinoid isolated from Picrolemma sprucei Hook. f., were evaluated in human promyelocytic leukemia c...
Date: 2020
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Origin: Oasisbr