88 documents found, page 1 of 9
A functional polymorphism in IL-36β modulates macrophage antifungal effector fu...
Gonçalves, Samuel M.; Leite, L.; de Vasconcelos, P.; Pereira, I.; Dewi, I. M. W.; Mercier, T.; Aerts, R.; Ligeiro, D.; Mendes, F.; Freitas, F.Background: Genetic predisposition plays a major role in the development of invasive pulmonary aspergillosis (IPA). The risk and course of IPA vary significantly among patients, yet continuously new genetic mechanisms that influence individual antifungal immune responses are being discovered. While genetic variability in interleukin (IL)-1 family cytokines is recognized as an important cause of disease suscepti...
Interferon gamma rebalances immunopathological signatures in chronic granulomat...
Bruno, M.; Kröger, C.; Ferreira, A. V.; Zhang, B.; Röring, R. J.; Liu, R.; van der Made, C. I.; van Rhijn, N.; Groh, L.; Klück, V.; Janssen, N. A. F.Chronic granulomatous disease (CGD) is a primary immunodeficiency characterized by recurrent life-threatening infections and hyperinflammatory complications. It is caused by mutations in the reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex and the consequent loss of reactive oxygen species (ROS) production. Recombinant human interferon gamma (rIFN-γ) prophylaxis reduces the risk of se...
Addressing critical fungal pathogens under a one health perspective: key insigh...
Sabino, R.; Antunes, F.; Araújo, R.; Bezerra, A. R.; Brandão, J.; Carneiro, C.; Carvalho, Agostinho; Carvalho, D.; Conceição, I. C.; Cota Medeiros, F.Fungal infections have emerged as a significant public health concern, especially with the increasing incidence of severe mycoses caused by pathogens such as Aspergillus fumigatus, Candida auris, Candida albicans, and Cryptococcus neoformans. These fungi, listed as critical priorities by the World Health Organization, pose a heightened risk due to rising antifungal resistance and their severe impact on immunoco...
Profiling bacteria in the lungs of patients with severe influenza versus COVID-...
Feys, Simon; Cardinali-Benigni, Martina; Lauwers, Hanne Moon; Jacobs, Cato; Stevaert, Annelies; Gonçalves, Samuel M; Cunha, Cristina; Debaveye, YvesRationale: The influence of the lung bacterial microbiome, including potential pathogens, in patients with influenza-associated pulmonary aspergillosis (IAPA) or coronavirus disease (COVID-19)-associated pulmonary aspergillosis (CAPA) has yet to be explored. Objectives: To explore the composition of the lung bacterial microbiome and its association with viral and fungal infection, immunity, and outcome in sever...
Akkermansia muciniphila and Parabacteroides distasonis synergistically protect ...
Gaifem, Joana; Mendes-Frias, Ana; Wolter, Mathis; Steimle, Alex; Garzón, Maria Jose; Ubeda, Carles; Nobre, Clarisse; González, Abigail; Pinho, Salomé S.The contribution of the gut microbiome to the balance between homeostasis and inflammation is widely known. Nevertheless, the etiology of inflammatory bowel disease, which is known to be influenced by genetics, immune response, and environmental cues, remains unclear. Unlocking novel players involved in the dictation of a protective gut, namely, in the microbiota component, is therefore crucial to develop novel...
Metabolic regulation of the host-fungus interaction: from biological principles...
Silva-Gomes, Rita; Caldeira, Inês; Fernandes, Raquel; Fernandes, Raquel; Cunha, Cristina; Carvalho, AgostinhoFungal infections present a significant global public health concern, impacting over 1 billion individuals worldwide and resulting in more than 3 million deaths annually. Despite considerable progress in recent years, the management of fungal infections remains challenging. The limited development of novel diagnostic and therapeutic approaches is largely attributed to our incomplete understanding of the pathoge...
Multicentric Study on the Clinical Mycology Capacity and Access to Antifungal T...
Fernandes, Raquel; Sabino, Raquel; Cunha, Cristina; Cornely, Oliver A.; Carvalho, Agostinho; Salmanton‑García, JonThe success of the clinical management of invasive fungal diseases (IFD) is highly dependent on suitable tools for timely and accurate diagnosis for effective treatment. An in-depth analysis of the ability of European institutions to promptly and accurately diagnose IFD was previously conducted to identify limitations and aspects to improve. Here, we evaluated and discussed the specific case of Portugal, for wh...
Comprehensive assessment of environmental fungus-reactive T cells response in h...
Santos, Rita F.; Coelho, Andreia L.; Rufo, João C.; Coelho, David; Gonçalves, Melany; Gonçalves, Samuel L.; Cunha, Cristina; Carvalho, AgostinhoHypersensitivity pneumonitis (HP) is an interstitial lung disease that results in parenchymal and small airways inflammation and culminates in breathlessness, negatively impacting patient’s quality of life and survival. HP is initiated by an exaggerated immune response triggered by the inhalation of a variety of environmental antigens. The identification of the triggering antigen is a cornerstone of the diagnos...
Echinacea purpurea fractions represent promising plant-based anti-inflammatory ...
Vieira, Sara Filipa Fontoura; Gonçalves, Samuel M.; Gonçalves, Virgínia M. F.; Llaguno, Carmen P.; Macías, Felipe; Tiritan, Maria ElizabethEchinacea purpurea is traditionally used in the treatment of inflammatory diseases. Therefore, we investigated the anti-inflammatory capacity of E. purpurea dichloromethanolic (DE) and ethanolic extracts obtained from flowers and roots (R). To identify the class of compounds responsible for the strongest bioactivity, the extracts were fractionated into phenol/carboxylic acid (F1) and alkylamide fraction (F2)...
Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosome...
Jia, Lei-Jie; Rafiq, Muhammad; Radosa, Lukáš; Hortschansky, Peter; Cunha, Cristina; Cseresnyés, Zoltán; Krüger, Thomas; Schmidt, FranziskaThe decision whether endosomes enter the degradative or recycling pathway in mammalian cells is of fundamental importance for pathogen killing, and its malfunctioning has pathological consequences. We discovered that human p11 is a critical factor for this decision. The HscA protein present on the conidial surface of the human-pathogenic fungus Aspergillus fumigatus anchors p11 on conidia-containing phagosomes ...