28 documents found, page 1 of 3
Bacterial nanocellulose as a simple and tailorable platform for controlled drug...
Costa, Lígia Francisca Rodrigues; Carvalho, Alexandre; Fernandes, António J. S.; Campos, Teresa; Dourado, Nuno; Costa, Florinda M.; Gama, F. M.In this study we present a proof of concept of a simple and straightforward approach for the development of a Bacterial Nanocellulose drug delivery system (BNC-DDS), envisioning the local delivery of immunomodulatory drugs to prevent foreign body reaction (FBR). Inspired by the self-adhesion behavior of BNC upon drying, we proposed a BNC laminate entrapping commercial crystalline drugs (dexamethasone-DEX and GW...
Treatment patterns and preferences of people living with HIV starting or switch...
Pedro, Liliana; Zagalo, Alexandra; Tavares, Raquel; Pacheco, Patrícia; Oliveira, Joaquim; Pinto, Inês Vaz; Serrão, Rosário; Tavares, SandraBackground: There is a lack of up-to-date real-life evidence on antiretroviral therapy (ART) strategies among people living with HIV (PLWH) in Portugal. This study aimed to describe the treatment strategy used in PLWH either initiating or switching ART. Methods: Non-interventional, cross-sectional, multicenter study carried out between December 2019 and October 2021 in Portugal. Results: A total of 237 PLWH wer...
Real-World Characterization of the Portuguese Population Living with HIV who In...
Serrão, Rosário; Mansinho, Kamal; Maltez, Fernando; Marques, Nuno; Carvalho, Alexandre; Pazos, Rosário; Zagalo, Alexandra; Mendez, JosefinaIntroduction: Although raltegravir has been available since 2007, data are lacking on the Portuguese population living with HIV who initiated this antiretroviral therapy. Hence, this study aimed to characterize the patients who initiated raltegravir-based regimens between January 2015 and December 2017, on sociodemographics, clinical features, and treatment satisfaction.Material and Methods: Observational, retr...
Occurrence of Healthcare-Associated Infections (HAIs) by Escherichia coli and K...
Machado, Elisabete; Costa, Patrício; Carvalho, AlexandreExtended-spectrum-β-lactamase (ESBL)- and carbapenemase-producing bacteria are widespread in hospitals, but the extent of this problem in long-term care facilities (LTCFs) is poorly understood. We aimed to elucidate, in the Portuguese regional clinical context, the relevance of LTCFs as a reservoir of <i>Escherichia coli</i> and <i>Klebsiella</i> spp. producing ESBL- and/or carbapenemases (Ec/Kp-ESBL/CARB). Fou...
Knowledge and Attitudes Towards COVID-19: A Cross-sectional Study in Portugal
Pires, Olga; Oliveira, Ana Andrade; Moreira, Pedro; Santa-Cruz, André; Carvalho, Alexandre; Alves, JoanaN/a.; N/a.
Sampling Methods and Risk Stratification Regarding Environmental Contamination ...
Mendes, Marta; Andrade Oliveira, Ana; Pires, Olga; Branca, Fernando; Beirão, Maria; Santa-Cruz, André; Carvalho, Alexandre; Alves, JoanaIntroduction: Transmission of COVID-19 through close contact and droplets is well established, but the influence of aerosol and surface contamination remains to be determined. Literature is scarce and inconsistent about the viable virus particles free-distance from infected patients, as well as about different swabbing methods for surface contamination evaluation. The aim of this study was to evaluate the most ...
Development of the HIV360 international core set of outcome measures for adults...
Marques‐Gomes, João; Salt, Matthew J.; Pereira‐Neto, Rita; Barteldes, Franca S.; Gouveia‐Barros, Vera; Carvalho, AlexandreObjectives: HIV outcomes centre primarily around clinical markers with limited focus on patient-reported outcomes. With a global trend towards capturing the outcomes that matter most to patients, there is agreement that standardizing the definition of value in HIV care is key to their incorporation. This study aims to address the lack of routine, standardized data in HIV care. Methods: An international working ...
Influence of laser structural patterning on the tribological performance of C-a...
Shamshiri, Mohammadreza; Manaia, Ana; Vuchkov, Todor; Carvalho, Alexandre; Gaspar, Guilherme; Fernandes, António; Dolatabadi, Samaneh HeydarianIn this paper, we are proposing for the first time the partial laser treatment of a self-lubricating coating in order to optimize its frictional performance from the very first moments of the sliding contact. W-S films alloyed with carbon were deposited by closed field unbalanced magnetron sputtering. The coatings were treated using two types of lasers, with peak emissions in the UV and IR, under different lase...
Characterization of a large cluster of HIV-1 A1 infections detected in Portugal...
Araújo, Pedro M. M.; Carvalho, Alexandre; Pingarilho, Marta; Abecasis, Ana B.; Osório, Nuno S.; Rodrigues, Fernando; Ramos, Helena; Neves, IsabelHIV-1 subtypes associate with differences in transmission and disease progression. Thus, the existence of geographic hotspots of subtype diversity deepens the complexity of HIV-1/AIDS control. The already high subtype diversity in Portugal seems to be increasing due to infections with sub-subtype A1 virus. We performed phylogenetic analysis of 65 A1 sequences newly obtained from 14 Portuguese hospitals and 425 ...
Characterization of a large cluster of HIV-1 A1 infections detected in Portugal...
Araújo, Pedro M. M.; Carvalho, Alexandre; Pingarilho, Marta; BEST-HOPE study group; Abecasis, Ana B.; Osório, Nuno S.HIV-1 subtypes associate with differences in transmission and disease progression. Thus, the existence of geographic hotspots of subtype diversity deepens the complexity of HIV-1/AIDS control. The already high subtype diversity in Portugal seems to be increasing due to infections with sub-subtype A1 virus. We performed phylogenetic analysis of 65 A1 sequences newly obtained from 14 Portuguese hospitals and 425 ...