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Practical Guidance on the Detection of NTRK Fusions in Sarcomas: Current Status...

Fernandes, Isabel; Macedo, Daniela; Gouveia, Emanuel; Ferreira, Ana; Lima, Jorge; Lopez, Dolores; Melo-Alvim, Cecília; Carvalho, Alice; Tavares, Paulo

Sarcomas are a rare and heterogeneous group of mesenchymal malignant tumors and account for approximately 1% of all adult cancers and around 20% of all pediatric solid tumors in Europe. Technology advances have enabled a more accurate and efficient characterization of the molecular mechanisms underlying the pathogenesis of sarcoma subtypes and revealed novel and unexpected therapeutic targets with prognostic/pr...

Date: 2025   |   Origin: Acta Médica Portuguesa

Tumor Recurrence versus Radiation-induced Stroke in a Child with a History of M...

Maia, Carolina; Pinto, Joana; Carvalho, Sílvia; Carvalho, Alice; Palavra, Filipe

Children with a history of central nervous system neoplasia, submitted to radiotherapy, have an increased risk of vascular complications that can be, clinically and imagiologically, very similar to a tumor recurrence. We describe the case of an 11-year-old child who, 10 years after diagnosis and treatment of a medulloblastoma, suddenly developed right hemiparesis. The initial imaging findings did not allow the ...

Date: 2023   |   Origin: SINAPSE

Football Player with Shoulder Pain

Coelho Almeida, Andre; Teixeira, Susana; Ornelas, Paula; Carvalho, Alice


Infundibuloneurohipofíse: Diagnóstico Diferencial da Diabetes Insípida Caso Clí...

Carvalho, Alice; Heitor, Fátima; Mirante, Mª Alice; Costa, José Aususto; Pais, Rui Pedro

Os diagnósticos diferenciais da forma central de diabetes insípida são vários: traumatismo» infecção malformação, neoplasia, situações inflamatórias diversas. Progressivamente» o número de casos considerado como diabetes insípida idiopática tem vindo a diminuir com a melhoria dos meios imagiológicos, nomeadamente Ressonância Magnética Nuclear. Descreve-se o caso de uma adolescente com diabetes insípida central»...


Gliomas do Quiasma Óptico na Criança: Avaliação Retrospectiva

Carvalho, Alice; Heitor, Fátima; Brito, Manuel; Baptista, Rui; Costa, José Augusto; Correia, Alexandre; Pais, Rui Pedro

Objectivos: As opções terapêuticas na abordagem do Glioma do Quiasma Óptico são várias, mas nenhuma isenta de complicações. Avaliou-se a resposta a diferentes terapêuticas e sequelas, nas crianças com Glioma do Quiasma Óptico, diagnosticadas no Hospital Pediátrico de Coimbra Material e Métodos: Analisaram-se 11 casos diagnosticados de 1984 até 1999 com idade 8 anos. Estabeleceram-se 2 grupos (Grupos A e B), de ...


Evaluation of the knowledge and attitudes to the standard precautions for infec...

Aires, Sofia; Carvalho, Alice; Aires, Ernestina; Calado, Elsa; Aragão, Irene; Oliveira, Júlio; Polónia, António; Vasconcelos, Carlos

The Standard Precautions are measures to prevent healthcare workers' exposure to infectious agents, like HIV, HBV and HCV, through the routine use of techniques and appropriate barriers that reduce the exposure probability. These measures intend to prevent contact with blood and other fluids, potentially infected, contributing to the reduction of nosocomial infection.To evaluate the knowledge, attitudes and adh...

Date: 2010   |   Origin: Acta Médica Portuguesa

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