4 documents found, page 1 of 1
The inflammatory status of soluble microenvironment influences the capacity of ...
Bogéa, Gabriela Muller Reche; Carvalho, Amandda Évelin Silva; Braga, Luma Dayane de Carvalho Filiú; Neves, Francisco de Assis RochaThe development of immunotherapeutic approaches for the treatment of melanoma requires a better understanding of immunoescape mechanisms of tumor cells and how they interact with other tumor-resident cell types. Here, we evaluated how the conditioned media of resting (rCM) and immune-activated PBMCs (iCM) influence the ability of a metastatic melanoma cell line (MeWo) to control T-cells function. MeWo cells wer...
Commentary : mesenchymal stem cells : a new piece in the puzzle of COVID-19 tre...
Carvalho, Juliana Lott; Melgaço Garcez, Emãnuella; Carvalho, Amandda Évelin Silva; Araujo, Felipe Saldanha deA Commentary on Mesenchymal Stem Cells: A New Piece in the Puzzle of COVID-19 Treatment By Saldanha-Araujo F, Melgaço Garcez E, Silva-Carvalho AE and Carvalho JL (2020). Front. Immunol. 11:1563. doi: 10.3389/fimmu.2020.01563.
Mesenchymal stem cells : a new piece in the puzzle of COVID-19 treatment
Araujo, Felipe Saldanha de; Melgaço Garcez, Emãnuella; Carvalho, Amandda Évelin Silva; Carvalho, Juliana LottCOVID-19 is a disease characterized by a strong inflammatory response in severe cases, which fails to respond to corticosteroid therapy. In the context of the current COVID-19 outbreak and the critical information gaps regarding the disease, several different therapeutic strategies are under investigation, including the use of stem cells. In the present manuscript, we provide an analysis of the rationale underl...
GVHD-derived plasma as a priming strategy of mesenchymal stem cells
Carvalho, Amandda Évelin Silva; Rodrigues, Leane Perim; Schiavinato, Josiane Lilian; Alborghetti, Marcos Rodrigo; Bettarello, GustavoBackground: Mesenchymal stem cell (MSC) therapy is an important alternative for GVHD treatment, but a third of patients fail to respond to such therapy. Therefore, strategies to enhance the immunosuppressive potential of MSCs constitute an active area of investigation. Here, we proposed an innovative priming strategy based on the plasma obtained from GVHD patients and tested whether this approach could enhance ...