10 documents found, page 1 of 1
The characterization and cytotoxic evaluation of chondrosia reniformis collagen...
Rocha, Miguel S.; Marques, Catarina F.; Carvalho, Ana C.; Martins, Eva; Ereskovsky, Alexander; Reis, Rui L.; Silva, Tiago H.Chondrosia reniformis is a collagen-rich marine sponge that is considered a sustainable and viable option for producing an alternative to mammalian-origin collagens. However, there is a lack of knowledge regarding the properties of collagen isolated from different sponge parts, namely the outer region, or cortex, (ectosome) and the inner region (choanosome), and how it affects the development of biomaterials. I...
Cell-laden marine gelatin methacryloyl hydrogels enriched with ascorbic acid fo...
Alves, Ana L.; Carvalho, Ana C.; Machado, Inês; Diogo, Gabriela S.; Fernandes, Emanuel M.; Castro, Vânia Isabel Baptista; Pires, Ricardo A.Corneal pathologies from infectious or noninfectious origin have a significant impact on the daily lives of millions of people worldwide. Despite the risk of organ rejection or infection, corneal transplantation is currently the only effective treatment. Finding safe and innovative strategies is the main goal of tissue-engineering-based approaches. In this study, the potential of gelatin methacryloyl (GelMA) hy...
Sulfated seaweed polysaccharides
Inácio, Ana Rita Matos; Carvalho, Ana C.; Oliveira, Catarina; Reys, Lara Priscila Lopes; Silva, Simone S.; Neves, N. M.; Martins, Albino; Reis, R. L.Mankind has used natural resources for many different applications, from food and clothes to drugs, but only recently is giving the due attention to the need for a responsible management of these resources toward sustainability. One of the approaches is to take the most out of its resources, addressing the several components of natural resources, which can be used in many industrial fields. In this regard, many...
Salmonella spp. in pet reptiles in Portugal : prevalence and chlorhexidine gluc...
Cota, João; Carvalho, Ana C.; Dias, Inês; Reisinho, Ana; Bernardo, F.; Oliveira, ManuelaABSTRACT - A fraction of human Salmonella infections is associated with direct contact with reptiles, yet the number of reptile-associated Salmonellosis cases are believed to be underestimated. Existing data on Salmonella spp. transmission by reptiles in Portugal is extremely scarce. The aim of the present work was to evaluate the prevalence of Salmonella spp. in pet reptiles (snakes, turtles, and lizards), as ...
Marine-derived biomaterials for cancer treatment
Oliveira, Catarina; Carvalho, Ana C.; Reis, R. L.; Neves, N. M.; Martins, Albino; Silva, Tiago H.Cancer treatments do not achieve the desired therapeutic effects so far, mainly due to unwanted side effects, specifically the toxicity to healthy tissues. The use of natural compounds, namely marine-derived biopolymers, may offer a promising alternative which will be the main focus of this book chapter. Since fucoidan and chitosan have been reported to present anticancer activity as single bioactive agents, ...
Ohmic heating extract of vine pruning residue has anti-colorectal cancer activi...
Jesus, Meirielly Santos; Carvalho, Ana C.; Teixeira, J. A.; Domingues, Lucília; Pereira-Wilson, CristinaVine pruning residues are by-products of the wine industry that have not received much attention in the past, in spite of being rich in bioactive compounds. In this study, we aimed to test whether an ohmic extract of vine pruning residue (VPE) has anti-colorectal cancer (CRC) properties, and whether responses differ according with cell’s mutation profile. VPE decreased human CRC cell proliferation, accompanied ...
New drugs from traditional medicines: pharmacological evaluation of plant extra...
Pinho, Cláudia; Oliveira, Ana; Paraíso, Nilson; Carvalho, Ana C.; Calçada, Carla; Lima, Cristovao F.; Dias, Alberto C.P.Plants are rich sources of medicines and Brazil is among the most biodiverse nations in the world.
Assessment of a protease inhibitor peptide for anti-ageing
Sá, M.; Azóia, Nuno G.; Carvalho, Ana C.; Silva, C.; Matamá, Maria Teresa; Gomes, Andreia C; Cavaco-Paulo, ArturAgeing and skin exposure to UV radiation induces production and activation of matrix metalloproteinases (MMPs) and human neutrophil elastase (HNE). These enzymes are known to break down the extracellular matrix (ECM) which leads to wrinkle formation. Here, we demonstrated the potential of a solid-in-oil nanodispersion containing a competitive inhibitor peptide of HNE mixed with hyaluronic acid (HA), displaying ...
Protein microspheres as suitable devices for piroxicam release
Paulo, Artur Cavaco; Silva, Raquel; Ferreira, Helena; Carvalho, Ana C.; Gomes, Andreia CBovine serum albumin-piroxicam (BSA-piroxicam) and human serum albumin-piroxicam (HSA-piroxicam) microspheres were sonochemically prepared and characterized. The use of polyvinyl alcohol (PVA) lead to an improvement of formulation characteristics, including smaller size, lower polydispersity index (PDl), higher entrapment efficiency and higher stability. The release kinetics of these proteinaceous microspheres ...
Electrochemical characterization of cobalt-based alloys using the mini-cell system
Nascimento, M. Lúcia; Mueller, Wolf-Dieter; Carvalho, Ana C.; Tomás, HelenaThe aim of this work was to investigate the electrochemical behavior of cobaltbased alloys of different compositions using the mini-cell system (MCS) and to test the sensitivity of this technique in the detection of variations in the electrochemical behavior caused by the different compositions of cobalt-based alloys. Methods. The electrochemical measurements were performed on two cobalt-based alloys, having a ...