12 documents found, page 1 of 2
A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line
Silva, Jéssica D.; Marques, Joana; Santos, Inês P.; Carvalho, Ana L. M. Batista de; Martins, Clara B.; Laginha, Raquel; Batista de Carvalho, Luís A. E.A dinuclear Pt(II) complex with putrescine as bridging polyamine ligand ([Pt2Put2(NH3)4]Cl4) was synthesized and assessed as to its potential anticancer activity against a human non-small cell lung cancer line (A549), as well as towards non-cancer cells (BEAS-2B). This effect was evaluated through in vitro cytotoxicity assays (MTT and SRB) coupled to microFTIR and microRaman spectroscopies, the former deliverin...
Evaluation of the Cytotoxic Effect of Pd2Spm against Prostate Cancer through Vi...
Laginha, Raquel C.; Martins, Clara B.; Brandão, Ana L.; Marques, Joana; Marques, M. P.aula M.; Batista de Carvalho, Luís A. E.; Santos, Inês P.Regarding the development of new antineoplastic agents, with a view to assess the selective antitumoral potential which aims at causing irreversible damage to cancer cells while preserving the integrity of their healthy counterparts, it is essential to evaluate the cytotoxic effects in both healthy and malignant human cell lines. In this study, a complex with two Pd(II) centers linked by the biogenic polyamine ...
Pd(II) and Pt(II) Trinuclear Chelates with Spermidine: Selective Anticancer Act...
Vojtek, Martin; Martins, Clara B.; Ramos, Raquel; Duarte, Sara Gomes; Ferreira, Isabel M. P. L. V. O.; Carvalho, Ana L. M. Batista deTriple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10-20% of all breast cancer cases. Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance often hamper their clinical use. Hence, novel drug entities with improved tolerability and selectivity profiles, as w...
Impact of Conventional and Potential New Metal-Based Drugs on Lipid Metabolism ...
Bispo, Daniela S. C.; Correia, Marlene; Carneiro, Tatiana J.; Martins, Ana S.; Reis, Aliana A. N.; Carvalho, Ana L. M. Batista de; Marques, Maria P. M.This work investigated the mechanisms of action of conventional drugs, cisplatin and oxaliplatin, and the potentially less deleterious drug Pd2Spermine (Spm) and its Pt(II) analog, against osteosarcoma MG-63 cells, using nuclear-magnetic-resonance metabolomics of the cellular lipidome. The Pt(II) chelates induced different responses, namely regarding polyunsaturated-fatty-acids (increased upon cisplatin), sugge...
Pd2Spermine Complex Shows Cancer Selectivity and Efficacy to Inhibit Growth of ...
Vojtek, Martin; Gonçalves-Monteiro, Salomé; Šeminská, Patrícia; Valová, Katarína; Bellón, Loreto; Dias-Pereira, Patrícia; Marques, FranklimPd2Spm is a dinuclear palladium(II)-spermine chelate with promising anticancer properties against triple-negative breast cancer (TNBC), a breast carcinoma subset with poor prognosis and limited treatment options. The present study evaluated the in vitro and in vivo anticancer effects of Pd2Spm compared to the reference metal-based drug cisplatin. Triple-negative breast cancer MDA-MB-231 cells, non-cancerous MCF...
Who's Who? Discrimination of Human Breast Cancer Cell Lines by Raman and FTIR M...
Santos, Inês Pereira dos; Martins, Clara B.; Batista de Carvalho, Luís A. E.; Marques, Maria P. M.; Carvalho, Ana L. M. Batista de(1) Breast cancer is presently the leading cause of death in women worldwide. This study aims at identifying molecular biomarkers of cancer in human breast cancer cells, in order to differentiate highly aggressive triple-negative from non-triple-negative cancers, as well as distinct triple-negative subtypes, which is currently an unmet clinical need paramount for an improved patient care. (2) Raman and FTIR (Fo...
Metabolic Impact of Anticancer Drugs Pd2Spermine and Cisplatin on the Brain of ...
Carneiro, Tatiana J.; Vojtek, Martin; Gonçalves-Monteiro, Salomé; Neves, João R.; Carvalho, Ana L. M. Batista de; Marques, Maria Paula M.; Diniz, CarmenThe new palladium agent Pd2Spermine (Spm) has been reported to exhibit promising cytotoxic properties, while potentially circumventing the known disadvantages associated to cisplatin therapeutics, namely acquired resistance and high toxicity. This work presents a nuclear magnetic resonance (NMR) metabolomics study of brain extracts obtained from healthy mice, to assess the metabolic impacts of the new Pd2Spm co...
A New Look into Cancer-A Review on the Contribution of Vibrational Spectroscopy...
Mamede, Adriana Maria Pires; Santos, Inês P.; Carvalho, Ana L. M. Batista de; Figueiredo, Paulo; Silva, Maria C.; Tavares, Mariana V.; Marques, M. P. M.In 2020, approximately 10 million people died of cancer, rendering this disease the second leading cause of death worldwide. Detecting cancer in its early stages is paramount for patients' prognosis and survival. Hence, the scientific and medical communities are engaged in improving both therapeutic strategies and diagnostic methodologies, beyond prevention. Optical vibrational spectroscopy has been shown to be...
Preclinical pharmacokinetics and biodistribution of Anticancer Dinuclear Pallad...
Vojtek, Martin; Gonçalves-Monteiro, Salomé; Pinto, Edgar; Kalivodová, Sára; Almeida, Agostinho; Marques, Maria P. M.; Carvalho, Ana L. M. Batista dePalladium-based compounds are regarded as potential analogs to platinum anticancer drugs with improved properties. The present study assessed the pharmacokinetics and biodistri bution of a dinuclear palladium(II)-spermine chelate (Pd2Spm), which has previously been shown to possess promising in vitro activity against several therapy-resistant cancers. Using inductively coupled plasma-mass spectrometry, the kine...
Novel insights into mice multi-organ metabolism upon exposure to a potential an...
Carneiro, Tatiana J.; Araújo, Rita; Vojtek, Martin; Gonçalves-Monteiro, Salomé; Diniz, Carmen; Carvalho, Ana L. M. Batista de; Marques, M. Paula M.Pd(II)-compounds are presently regarded as promising anticancer drugs, as an alternative to Pt(II)-based drugs (e.g., cisplatin), which typically trigger severe side-effects and acquired resistance. Dinuclear Pd(II) complexes with biogenic polyamines such as spermine (Pd2Spm) have exhibited particularly beneficial cytotoxic properties, hence unveiling the importance of understanding their impact on organism met...