11 documents found, page 1 of 2
Hippotherapy improves gross motor function in children with cerebral palsy: evi...
Bernardino, Inês; Borges, Daniel Filipe; Casalta Lopes, João; Soares, Joana Isabel; Borges, Daniel Filipe"Hippotherapy uses horse movement to promote physical and psychosocial rehabilitation and may benefit children with cerebral palsy (CP). Standardised instruments such as the Activity Scale for Kids-Performance (ASK©), the Gross Motor Function Classification System (GMFCS) and the Gross Motor Function Measure (GMFM) are needed to quantify effects on motor function. To systematically review the effects of hippoth...
Decoding Musical Valence and Arousal: Exploring the Neural Correlates of Music-...
Sayal, Alexandre; Guedes, Ana Gabriela; Almeida, Inês A. T.; Jardim Pereira, Daniela; Lima, César F.; Panda, Renato; Paiva, Rui Pedro; Sousa, TeresaMusic conveys both basic emotions, like joy and sadness, and complex ones, such as tenderness and nostalgia. Its effects on emotion regulation and reward have attracted much research attention, as the neural correlates of music-evoked emotions may inform neurorehabilitation interventions. Here, we used fMRI to decode and examine the neural correlates of perceived valence and arousal in music excerpts. Twenty pa...
Motor Cortex Excitation/Inhibition Imbalance in Young Adults With Autism Spectr...
Bernardino, Inês; Dionísio, Ana; Violante, Inês R.; Monteiro, Raquel; Castelo-Branco, MiguelExcitatory/inhibitory imbalance has been suggested as a neurobiological substrate of the cognitive symptomatology in Autism Spectrum Disorder (ASD). Studies using magnetic resonance spectroscopy (MRS) attempted to characterize GABA and Glutamate brain levels in ASD. However mixed findings have been reported. Here, we characterize both neurochemical and physiological aspects of GABA system in ASD by implementing...
Cortical inhibition in neurofibromatosis type 1 is modulated by lovastatin, as ...
Bernardino, Inês; Dionísio, Ana; Castelo Branco, MiguelNeurofibromatosis type 1 (NF1) is associated with GABAergic dysfunction which has been suggested as the underlying cause of cognitive impairments. Previous intervention trials investigated the statins' effects using cognitive outcome measures. However, available outcome measures have led to inconclusive results and there is a need to identify other options. Here, we aimed at investigating alternative outcome me...
Intracranial recordings in humans reveal specific hippocampal spectral and dors...
Castelhano, João; Duarte, Isabel; Bernardino, Inês; Pelle, Federica; Francione, Stefano; Sales, Francisco; Branco, Miguel CasteloInvasive brain recordings using many electrodes across a wide range of tasks provide a unique opportunity to study the role of oscillatory patterning and functional connectivity. We used large-scale recordings (stereo EEG) within and beyond the human hippocampus to investigate the role of distinct frequency oscillations during real-time execution of visual, attention and memory tasks in eight epileptic patients...
A Feasibility Clinical Trial to Improve Social Attention in Autistic Spectrum D...
Amaral, Carlos; Mouga, Susana; Simões, Marco; Pereira, Helena C.; Bernardino, Inês; Quental, Hugo; Playle, Rebecca; McNamara, Rachel; Oliveira, GuiomarDeficits in the interpretation of others' intentions from gaze-direction or other social attention cues are well-recognized in ASD. Here we investigated whether an EEG brain computer interface (BCI) can be used to train social cognition skills in ASD patients. We performed a single-arm feasibility clinical trial and enrolled 15 participants (mean age 22y 2m) with high-functioning ASD (mean full-scale IQ 103). P...
Oscillatory motor patterning is impaired in neurofibromatosis type 1: a behavio...
Silva, Gilberto; Duarte, Isabel Catarina; Bernardino, Inês; Marques, Tânia; Violante, Inês R; Castelo-Branco, MiguelNeurofibromatosis type1 (NF1) is associated with a broad range of behavioural deficits, and an imbalance between excitatory and inhibitory neurotransmission has been postulated in this disorder. Inhibition is involved in the control of frequency and stability of motor rhythms. Therefore, we aimed to explore the link between behavioural motor control, brain rhythms and brain activity, as assessed by EEG and fMRI...
Abnormal relationship between GABA, neurophysiology and impulsive behavior in n...
Ribeiro, Maria J.; Violante, Inês R; Bernardino, Inês; Edden, Richard A E; Castelo-Branco, MiguelNeurofibromatosis type 1 (NF1) is a neurodevelopmental disorder characterized by a broad spectrum of cognitive deficits. In particular, executive dysfunction is recognized as a core deficit of NF1, including impairments in executive attention and inhibitory control. Yet, the neural mechanisms behind these important deficits are still unknown. Here, we studied inhibitory control in a visual go/no-go task in chil...
Investigation of the dorsal stream hypothesis in Williams syndrome
Bernardino, InêsTese de doutoramento em Ciências da Saúde, Ramo de Ciências Biomédicas, apresentada à Faculdade de Medicina da Universidade de Coimbra; O Síndrome de Williams (SW) é uma perturbação genética rara do neurodesenvolvimento caracterizada por alterações sensoriais, cognitivas e neuroanatómicas. Esta patologia constitui, por isso, um modelo ímpar para investigar a natureza modular (ou não) dos processos cognitivos, d...
Abnormal brain activation in neurofibromatosis type 1: a link between visual pr...
Violante, Inês R.; Ribeiro, Maria J.; Cunha, Gil; Bernardino, Inês; Duarte, João V.; Ramos, Fabiana; Saraiva, Jorge; Silva, EduardoNeurofibromatosis type 1 (NF1) is one of the most common single gene disorders affecting the human nervous system with a high incidence of cognitive deficits, particularly visuospatial. Nevertheless, neurophysiological alterations in low-level visual processing that could be relevant to explain the cognitive phenotype are poorly understood. Here we used functional magnetic resonance imaging (fMRI) to study earl...