3 documents found, page 1 of 1
New antigens for the serological diagnosis of human visceral leishmaniasis iden...
Carvalho, Ana Maria Ravena Severino; Mendes, Tiago Antônio de Oliveira; Coelho, Eduardo Antonio Ferraz; Duarte, Mariana Costa; Menezes- Souza, DanielVisceral leishmaniasis (VL) still represents a serious public health problem in Brazil due to the inefficiency of the control measures currently employed, that included early diagnosis and treatment of human cases, vector control, euthanasia of infected dogs and, recently approved in Brazil, treatment with Milteforam drug. Effective clinical management depend largely on early and unequivocal diagnosis, however,...
Immunogenomic screening approach to identify new antigens for the serological d...
Elisei, Rutyanne Maria Tonelli; Matos, Christiane Santos; Carvalho, Ana Maria Ravena Severino; Chaves, Ana Thereza; Medeiros, Fernanda Alvarenga CardosoSerological tests are preferentially used for the diagnosis of Chagas’ disease (CD) during the chronic phase because of the low parasitemia and high anti-Trypanosoma cruzi antibody titers. However, the current methods showed several disadvantages, as contradictory or inconclusive results, mainly related to the characteristics of the antigens used, in general, crude or whole parasites, but also due to antigen pr...
Treatment of murine visceral leishmaniasis using an 8-hydroxyquinoline-containi...
Duarte, Mariana Costa; Lage, Letícia Martins dos Reis; Lage, Daniela Pagliara; Martins, Vivian Tamietti; Carvalho, Ana Maria Ravena SeverinoNewtherapeutics are urgently needed to treat visceral leishmaniasis (VL). Due to the fact that drug discovery is a long and expensive process, the development of delivery systems to carry old and toxic drugs could be considered, as well as the evaluation of new molecules that have already shown to present biological activity. In this context, the present study evaluated the in vitro and in vivo antileishmanial ...