73 documents found, page 1 of 8
Metabolic reprogramming regulates histone lactylation during zebrafish caudal f...
Borbinha, Jorge; Lourenço, Raquel; Brandão, Ana S.; Ribeiro, Daniel; Carvalho, Ana Sofia; Matthiesen, Rune; Jacinto, AntónioTissue regeneration relies on precise molecular mechanisms controlling cell-fate transitions, with metabolism emerging as a key regulator. Lactate-derived histone lactylation has recently been identified as an epigenetic modification regulating gene expression across various biological processes. Here, we report an increase in global histone lactylation in the mesenchyme and osteoblasts of the zebrafish caudal ...
LAMP2A regulates endosomal protein composition and membrane identity in exosome...
Ferreira, Joao Vasco; Ferraz, Luís Carvalho; da Rosa Soares, Ana; Ejtehadifar, Mostafa; Carvalho, Ana Sofia; Hall, Michael James; Morello, JuditThe endolysosomal system maintains cellular homeostasis through protein degradation and the release of exosomes that mediate intercellular communication. LAMP2A, a transmembrane protein, has been implicated in selective cargo loading into exosomes, or eLLoC. Here, we investigated how LAMP2A influences endosomal protein composition and function using mass spectrometry of endosomal and exosomal fractions from hum...
New trends on research and innovation 2025: extended abstracts
Brivio, Elena di Carpegna; Alcobia, João; Ning, Jane; Cabral, Ricardo; Canarias, Vitor; Assis, João de Sousa; Moldavan, Lubov; Pimenowa, OlenaEXPLORE AND MANAGE PARTNERSHIP IN THE KNOWLEDGE EXCHANGE WORLD BEHAVIORAL ECONOMICS AND MORAL EMOTIONS: THE CASE OF THE GIG ECONOMY POLLUTION OF AGRICULTURAL LANDS AND INNOVATIVE APPROACHES TO THEIR RESTORATION THE CRISIS IN FOOD MARKET AND THAILAND’S COMPETITION LAW BUSINESS PROCESS MANAGEMENT DRIVES DIGITAL TRANSFORMATION PORTUGAL’S PUBLIC SECTOR WAGE BILL EVOLUTION (1986–2023): AUSTERITY, STRUCTURAL REFORMS,...
Breakthroughs and pitfalls of using digital technologies in the LSP classroom: ...
Ferro, Maria João; Gómez Bautista, Alberto; Carvalho, Ana SofiaThe integration of digital technologies in language for specific purposes classrooms has become a prominent area of research and practice. This integration has brought about several breakthroughs but also some associated pitfalls. We provide an overview of the introduction of digital technologies in education, taking into consideration that one of the fundamental aims of the United Nations’ sustainable developm...
Beyond work: The role of “Family-Friendly” practices in the subjective well-bei...
Lopes, Sílvia; Couto, Rita; Rodrigues, Anabela; Sabino, Ana; Oliveira, Íris M.; C. Dias, Paulo; Carvalho, Ana SofiaDuring the COVID-19 pandemic, telework emerged as a pivotal strategy to mitigate the spread of the virus. However, telework’s feasibility was contingent on job roles. This gave rise to two distinct groups: teleworkers and on-site workers. However, the impacts of social support and well-being extended to both groups. This study investigated the link between organisational and supervisory family support and subje...
Breakthroughs and pitfalls of using digital technologies in the LSP classroom: ...
Ferro, Maria João; Gómez Bautista, Alberto; Carvalho, Ana SofiaThe integration of digital technologies in language for specific purposes classrooms has become a prominent area of research and practice. This integration has brought about several breakthroughs but also some associated pitfalls. We provide an overview of the introduction of digital technologies in education, taking into consideration that one of the fundamental aims of the United Nations’ sustainable developm...
Bioethics in Genetics: between science and art
Soares, Ana Rita; Carvalho, Ana SofiaMedical Genetics is a transversal and multidisciplinary medical speciality whose activity encompasses, in a general and simplistic perspective, the diagnosis of rare genetic diseases and genetic counselling of hereditary pathologies. Genetic information is, more than medical information, health information and it has implications not only for the self but also for family members. Although this medical specializ...
IgG+ Extracellular Vesicles Measure Therapeutic Response in Advanced Pancreatic...
Couto, Nuno; Elzanowska, Julia; Maia, Joana; Batista, Silvia; Pereira, Catarina Esteves; Beck, Hans Christian; Carvalho, Ana Sofia(1) Background: Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second-leading cause of cancer deaths by 2030. Imaging techniques are the standard for monitoring the therapy response in PDAC, but these techniques have considerable limits, including delayed disease progression detection and difficulty in distinguishing benign from malignant lesions. Extracellular vesicle (EV) liquid biopsy is an em...
Lupus pericarditis: chest pain and fever amidst COVID19 pandemic
Costa, Gustavo Gonçalves; Pereira, André Rosas; Carvalho, Ana SofiaIntroduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease of unknown cause with multisystemic involvement. In Portugal, it is estimated that 0.07% of the population has this diagnosis, with the first symptoms manifesting in the age group of 16 to 49 years old in 75% of the cases. The clinical manifestations of SLE are multiple and are related to the multisystemic character of...
Estratégia Nacional para a Medicina Genómica - PT_MedGen: desafios e prioridades
Almeida, Fernando de; Vicente, Astrid Moura; Calado, Patrícia; Santos, Manuel; Carvalho, Ana Sofia; Águas, Cíntia; Pinto, Cátia SousaO presente documento visa propor o conceito e as linhas de ação prioritárias da Estratégia Nacional para a Medicina Genómica (PT_MedGen). O documento baseia-se na auscultação de alguns dos principais stakeholders nacionais, representados na Comissão nomeada pelo Despacho n.o 5135/2021 coordenada pelo INSA, e ainda na consulta de outras entidades e peritos de relevância. A estratégia PT_MedGen tem a meta global ...