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Sorting nexin 3 mutation impairs development and neuronal function in Caenorhab...

Vieira, Neide; Bessa, Carlos; Rodrigues, Ana J.; Marques, Paulo; Chan, Fung-Yi; Carvalho, Ana Xavier de; Neves, Margarida Correia; Sousa, Nuno

The sorting nexins family of proteins (SNXs) plays pleiotropic functions in protein trafficking and intracellular signaling and has been associated with several disorders, namely Alzheimer's disease and Down's syndrome. Despite the growing association of SNXs with neurodegeneration, not much is known about their function in the nervous system. The aim of this work was to use the nematode Caenorhabditis elegans ...

Date: 2018   |   Origin: RepositóriUM - Universidade do Minho
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