32 documents found, page 1 of 4
Tripeptides featuring dehydrophenylalanine and homophenylalanine: homo- versus ...
Carvalho, André F.; Pereira, Teresa; Oliveira, Carlos; Figueiredo, Pedro; Carvalho, Alexandra; Pereira, David M.; Hilliou, L.; Bañobre-López, ManuelOver the years, our research group developed dehydrodipeptides N-capped with aromatic moieties as protease-resistant efficacious hydrogelators, affording self-assembled hydrogels at low (critical) concentrations. Dehydrotripeptides, with different dipeptide sequences and (D,L) stereochemistry, open a wider chemical space for the development of self-assembled soft nanomaterials. In this work, a small library of ...
Food addiction: prevalence, psychopathological correlates and associations with...
Nunes-Neto, Paulo R.; Köhler, Cristiano A.; Schuch, Felipe B.; Solmi, Marco; Quevedo, João; Maes, Michael; Murru, Andrea; Vieta, EduardObjective: To determine the prevalence of food addiction in a large Brazilian non-clinical sample. Sociodemographic and psychopathological correlates of food addiction as well as associations with quality (QoL) domains were also investigated. Methods: This cross-sectional study obtained data from a Brazilian anonymous web-based research platform (N = 7639; 71.3% females). Participants provided sociodemographic ...
Add-on treatment with curcumin has antidepressive effects in thai patients with...
Kanchanatawan, Buranee; Tangwongchai, Sookjaroen; Sughondhabhirom, Atapol; Suppapitiporn, Siriluck; Hemrunrojn, Solaphat; Carvalho, André F.Activation of immune-inflammatory and oxidative-nitrosative (IO&NS) stress pathways plays a role in major depression (MDD). Evidence suggests that curcumin (500–1000 mg/day), a polyphenol with strong anti-IO&NS properties, may have efficacy either as monotherapy or as an adjunctive treatment for depression. Further controlled trials with extended treatment periods (> 8 weeks) and higher curcumin doses are warra...
Relationship between sedentary behavior and depression: A mediation analysis of...
Stubbs, Brendon; Vancampfort, Davy; Firth, Joseph; Schuch, Felipe B.; Hallgren, Mats; Smith, Lee; Gardner, Benjamin; Kahl, Kai G.; Veronese, NicolaBackground: Sedentary behavior (SB) is associated with diabetes, cardiovascular disease and low mood. There is a paucity of multi-national research investigating SB and depression, particularly among low- and middle-income countries. This study investigated the association between SB and depression, and factors which influence this. Methods: Cross-sectional data were analyzed from the World Health Organization'...
In schizophrenia, depression, anxiety, and physiosomatic symptoms are strongly ...
Kanchanatawan, Buranee; Thika, Supaksorn; Sirivichayakul, Sunee; Carvalho, André F.; Geffard, Michel; Maes, MichaelThe depression, anxiety and physiosomatic symptoms (DAPS) of schizophrenia are associated with negative symptoms and changes in tryptophan catabolite (TRYCAT) patterning. The aim of this study is to delineate the associations between DAPS and psychosis, hostility, excitation, and mannerism (PHEM) symptoms, cognitive tests as measured using the Consortium to Establish a Registry for Alzheimer ’ s Disease (CERAD)...
The putative role of oxidative stress and inflammation in the pathophysiology o...
Morris, Gerwyn; Stubbs, Brendon; Köhler, Cristiano A.; Walder, Ken; Slyepchenko, Anastasiya; Berk, Michael; Carvalho, André F.Sleep and circadian abnormalities are prevalent and burdensome manifestations of diverse neuro-immune diseases, and may aggravate the course of several neuropsychiatric disorders. The underlying pathophysiology of sleep abnormalities across neuropsychiatric disorders remains unclear, and may involve the inter-play of several clinical variables and mechanistic pathways. In this review, we propose a heuristic fra...
The endoplasmic reticulum stress response in neuroprogressive diseases: emergin...
Morris, Gerwyn; Puri, Basant K.; Walder, Ken; Berk, Michael; Stubbs, Brendon; Maes, Michael; Carvalho, André F.The endoplasmic reticulum (ER) is the main cellular organelle involved in protein synthesis, assembly and secretion. Accumulating evidence shows that across several neurodegenerative and neuroprogressive diseases, ER stress ensues, which is accompanied by over-activation of the unfolded protein response (UPR). Although the UPR could initially serve adaptive purposes in conditions associated with higher cellular...
Major differences in neurooxidative and neuronitrosative stress pathways betwee...
Maes, Michael; Bonifacio, Kamila Landucci; Morelli, Nayara Rampazzo; Vargas, Heber Odebrecht; Barbosa, Décio Sabbatini; Carvalho, André F.Accumulating evidence indicates that oxidative and nitrosative stress (O&NS) pathways play a key role in the pathophysiology of bipolar disorder (BD) and major depressive disorder (MDD). However, only a handful of studies have directly compared alterations in O&NS pathways among patients with MDD and BD types I (BPI) and BPII. Thus, the current study compared superoxide dismutase (SOD1), lipid hydroperoxides (L...
Generalized anxiety disorder (GAD) and comorbid major depression with GAD are c...
Maes, Michael M; Bonifacio, Kamila Landucci; Morelli, Nayara Rampazzo; Vargas, Heber Odebrecht V; Moreira, Estefânia GastaldelloAccumulating evidence shows that nitro-oxidative pathways play an important role in the pathophysiology of major depressive disorder (MDD) and bipolar disorder (BD) and maybe anxiety disorders. The current study aims to examine superoxide dismutase (SOD1), catalase, lipid hydroperoxides (LOOH), nitric oxide metabolites (NOx), advanced oxidation protein products (AOPP), malondialdehyde (MDA), glutathione (GSH), ...
Imaging genetics paradigms in depression research: systematic review and meta-a...
Pereira, Lícia P.; Köhler, Cristiano A.; Stubbs, Brendon; Miskowiak, Kamilla W.; Morris, Gerwyn; Freitas, Bárbara P. de Freitas; Thompson, TrevorImaging genetics studies involving participants with major depressive disorder (MDD) have expanded. Nevertheless, findings have been inconsistent. Thus, we conducted a systematic review and meta-analysis of imaging genetics studies that enrolled MDD participants across major databases through June 30th, 2017. Sixtyfive studies met eligibility criteria (N=4034 MDD participants and 3293 controls), and there was s...