13 documents found, page 1 of 2
Comprehensive molecular landscape of cetuximab resistance in head and neck canc...
Gomes, Izabela N. F.; Silva-Oliveira, Renato J. da; Silva, Luciane Sussuchi da; Martinho, Olga; Evangelista, Adriane F.; Helvoort Lengert, André vanCetuximab is the sole anti-EGFR monoclonal antibody that is FDA approved to treat head and neck squamous cell carcinoma (HNSCC). However, no predictive biomarkers of cetuximab response are known for HNSCC. Herein, we address the molecular mechanisms underlying cetuximab resistance in an in vitro model. We established a cetuximab resistant model (FaDu), using increased cetuximab concentrations for more than eigh...
The role of single-nucleotide polymorphism (SNPs) in toxicity of induction chem...
De Marchi, Pedro; Melendez, Matias E.; Laus, Ana C.; Kuhlmann, Pamela A.; de Carvalho, Ana Carolina; Arantes, Lidia Maria R.B.; Evangelista, Adriane F.Made available in DSpace on 2022-04-28T19:27:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-11-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Background: Induction chemotherapy in locally-advanced head and neck squamous cell carcinoma (LAHNSCC) patients is potentially associated to serious adverse events. Biomarkers associated with toxicity could tailor its indication. This...
One-carbon metabolism and global DNA methylation in mothers of individuals with...
Mendes, Cristiani Cortez; Zampieri, Bruna Lancia; Arantes, Lidia Maria Rebolho Batista; Melendez, Matias Eliseo; Biselli, Joice Matos [UNESP]Made available in DSpace on 2022-04-29T08:32:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-01; Down syndrome (DS) is the most common chromosomal disorder, resulting from the failure of normal chromosome 21 segregation. Studies have suggested that impairments within the one-carbon metabolic pathway can be of relevance for the global genome instability observed in mothers of individuals with DS. Ba...
A simple architecture with self-assembled monolayers to build immunosensors for...
Soares, Andrey Coatrini; Soares, Juliana Coatrini; Shimizu, Flavio Makoto; Rodrigues, Valquiria da Cruz; Awan, Iram Taj; Melendez, Matias EliseoThe challenge of the early diagnosis of pancreatic cancer in routine clinical practice requires low-cost means of detection, and this may be achieved with immunosensors based on electrical or electrochemical principles. In this paper, we report a potentially low-cost immunosensor built with interdigitated gold electrodes coated with a self-assembled monolayer and a layer of anti-CA19-9 antibodies, which is capa...
Construction and characterization of a new TRAIL soluble form, active at picomo...
Melendez, Matias Eliseo; Silva-Oliveira, Renato José; Silva Almeida Vicente, Anna Luiza; Rebolho Batista Arantes, Lidia Maria; Carolina de Carvalho, AnaApoptosis induction has emerged as a treatment option for anticancer therapy. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a type II transmembrane protein, is a potent and specific pro-apoptotic protein ligand, which activates the extrinsic apoptosis pathway of the cell death receptors. Here we describe the construction and characterization of a new soluble TRAIL, sfTRAIL, stabilized with th...
AKT can modulate the in vitro response of HNSCC cells to irreversible EGFR inhi...
Silva-Oliveira, Renato José; Melendez, Matias; Martinho, Olga; Zanon, Maicon F.; Viana, Luciano de Souza; Carvalho, André Lopes; Reis, R. M.Epidermal growth factor receptor (EGFR) is overexpressed in up to 90% of head and neck squamous cell carcinoma (HNSCC) tumors. Cetuximab is the first targeted (anti-EGFR) therapy approved for the treatment of HNSCC patients. However, its efficacy is limited due to primary and secondary resistance, and there is no predict biomarkers of response. New generation of EGFR inhibitors with pan HER targeting and irreve...
Immunosensor for pancreatic cancer based on electrospun nanofibers coated with ...
Soares, Juliana C.; Iwaki, Leonardo E. O.; Soares, Andrey C.; Rodrigues, Valquiria C.; Melendez, Matias Eliseo; Fregnani, José Humberto T. G.We report the fabrication of immunosensors based on nanostructured mats of electrospun nanofibers of polyamide 6 and poly(allylamine hydrochloride) coated either with multiwalled carbon nanotubes (MWCNTs) or gold nanoparticles (AuNPs), whose three-dimensional structure was suitable for the immobilization of anti-CA19-9 antibodies to detect the pancreatic cancer biomarker CA19-9. Using impedance spectroscopy, th...
Identification of hereditary cancer in the general population: development and ...
Campacci, Natália; Lima, Juliana O. de; Carvalho, André Lopes; Michelli, Rodrigo A. D.; Haikel Junior, Raphael L.; Mauad, Edmundo; Viana, DaniloOne of the challenges for Latin American countries is to include in their healthcare systems technologies that can be applied to hereditary cancer detection and management. The aim of the study is to create and validate a questionnaire to identify individuals with possible risk for hereditary cancer predisposition syndromes (HCPS), using different strategies in a Cancer Prevention Service in Brazil. The primary...
Detection of human papillomavirus in laryngeal squamous cell carcinoma: systema...
Gama, Ricardo Ribeiro Gama; Carvalho, André Lopes; Longatto Filho, Adhemar; Scorsato, Anderson Paulo; Mendoza Lopez, Rossana V.; Rautava, JaanaBackground: Recent studies have reported a human papillomavirus (HPV) prevalence of 20% to 30% in laryngeal squamous cell carcinoma (LSCC), although clinical data on HPV involvement remain largely inconsistent, ascribed by some to differences in HPV detection methods or in geographic origin of the studies. Objective To perform a systematic review and formal meta-analysis of the literature reporting on HPV detec...
In vitro and in vivo analysis of RTK inhibitor efficacy and identification of i...
Martinho, Olga; Oliveira, Renato José Silva; Gonçalves, Vera M.; Clara, Carlos; Almeida, José Reynaldo; Carvalho, André Lopes; Barata, João TabordaTreatment for glioblastoma consists of radiotherapy and temozolomide-based chemotherapy. However, virtually all patients recur, leading to a fatal outcome. Receptor tyrosine kinase (RTK)-targeted therapy has been the focus of attention in novel treatment options for these patients. Here, we compared the efficacy of imatinib, sunitinib, and cediranib in glioblastoma models. In the present work, the biologic effe...