3 documents found, page 1 of 1
Selective impact of Tau loss on nociceptive primary afferents and pain sensation
Sotiropoulos, I.; Lopes, André T.; Pinto, Vítor; Lopes, Sofia; Carlos, Sara; Silva, Sara Carina Duarte; Carvalho, Andreia Alexandra Neves deTau protein hyperphosphorylation and consequent malfunction are hallmarks of Alzheimer's disease pathology; importantly, pain perception is diminished in these patients. In physiological conditions, Tau contributes to cytoskeletal dynamics and in this way, influences a number of cellular mechanisms including axonal trafficking, myelination and synaptic plasticity, processes that are also implicated in pain perc...
When gaining is loosing: insights into the function of ataxin-3 and its perturb...
Carvalho, Andreia Alexandra Neves deAtaxin-3 (ATXN3) is the protein involved in Machado-Joseph Disease (MJD), one of the nine neurodegenerative disorders known to be caused by a polyglutamine (polyQ) expansion. This polyQ tract causes the appearance of misfolded protein species, protein aggregates, neuronal dysfunction and cell death. ATXN3 is known to interact with polyubiquitin chains and to have deubiquitylating (DUB) activity in vitro, but it...
Increased thermotolerance in the absence of ataxin-3 in C. elegans
Carvalho, Andreia Alexandra Neves deAtaxin-3 is the protein involved in Machado-Joseph disease, one of the nine neurodegenerative disorders caused by a polyglutamine (polyQ) expansion. This polyQ expansion causes the appearance of misfolded protein species, aggregates, neuronal dysfunction and cell death. Ataxin-3 is a deubiquitylating (DUB) enzyme in vitro, is able to bind ubiquitin and ubiquitylated substrates and has been involved in the prote...