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Aurora A triggers Lgl cortical release during symmetric division to control pla...

Carvalho, CA; Moreira, S; Ventura, G; Sunkel, CE; Morais-de-Sá, E

Mitotic spindle orientation is essential to control cell-fate specification and epithelial architecture. The tumor suppressor Lgl localizes to the basolateral cortex of epithelial cells, where it acts together with Dlg and Scrib to organize apicobasal polarity. Dlg and Scrib also control planar spindle orientation, but how the organization of polarity complexes is adjusted to control symmetric division is large...

Date: 2015   |   Origin: Repositório Aberto da Universidade do Porto
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