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Development and validation of an analytical method to quantify cytotoxic drugs ...

Silva, Clara; Carmo, Helena; Oliveira, Vânia; Carvalho, Daniel; Moreira, Fernando

Background: Despite patient´s benefits, healthcare professionals face occupational hazardous when handling cytotoxic drugs used for cancer treatment [1]. Several organizations outline procedures, conditions, and equipment recommended for safe handling. The International Society of Oncology Pharmacy Practice (ISOPP) standards [2] are the guidelines recommended by the European Parliament but, unlike others (e.g. ...

Date: 2024   |   Origin: Scientific Letters

Métodos cromatográficos desenvolvidos para a quantificação de Quercetina extraí...

Carvalho, Daniel; Pinho, Cláudia; Ferraz Oliveira, Rita; Moreira, Fernando; Oliveira, Ana

A quercetina é o flavonoide mais utilizado no tratamento de várias doenças, exibindo propriedades antioxidantes, anti-inflamatórias, cardiovasculares, anticancerígenas e de proteção gástrica (Grande et al., 2016). A quercetina pode ser encontrada em várias frutas, vegetais e plantas, e a validação de métodos analíticos para quantificar a quercetina nas mais variadas matrizes é crucial (Singh et al., 2021).


Development and validation of an analytical method to quantify cytotoxic drugs ...

Silva, Clara; Carmo, Helena; Oliveira, Vânia; Carvalho, Daniel; Moreira, Fernando

Despite patient ́s benefits, healthcare professionals face occupational hazardous when handling cytotoxic drugs used for cancer treatment. Several organizations outline procedures, conditions, and equipment recommended for safe handling. The International Society of Oncology Pharmacy Practice (ISOPP) standards are the guidelines recommended by the European Parliament but, unlike others (e.g. Occupational Safety...


Análise de resíduos de 5-fluorouracilo no exterior de bombas infusoras após rea...

Cardoso, Andreia; Barreiros, Luísa; Sá, Maria dos Anjos; Sousa, Eulália; Carvalho, Daniel; Correia, Patrícia; Moreira, Fernando

Pese embora os benefícios potenciais da administração infusional de 5-fluorouracilo (5-FU) em regime de domicílio, já existiram relatos de derrames e resíduos de 5-FU no exterior de bombas infusoras, que reforça a necessidade do desenvolvimento e aplicação de metodologia analítica que permita a sua deteção e quantificação (Chefchaouni et al., 2023). 


The sound of silence: Quantification of typical absence seizures by sonifying E...

Borges, Daniel Filipe; Fernandes, João; Soares, Joana Isabel; Casalta‐Lopes, João; Carvalho, Daniel; Beniczky, Sándor; Leal, Alberto

Objective: To develop and validate a method for long- term (24- h) objective quantification of absence seizures in the EEG of patients with childhood absence epilepsy (CAE) in their real home environment using a wearable device (waEEG), comparing automatic detection methods with auditory recognition after seizure sonification. Methods: The waEEG recording was acquired with two scalp electrodes. Automatic analys...


The sound of silence: Quantification of typical absence seizures by sonifying E...

Borges, Daniel Filipe; Fernandes, João; Soares, Joana Isabel; Casalta‐Lopes, João; Carvalho, Daniel; Beniczky, Sándor; Leal, Alberto

To develop and validate a method for long-term (24-h) objective quantification of absence seizures in the EEG of patients with childhood absence epilepsy (CAE) in their real home environment using a wearable device (waEEG), comparing automatic detection methods with auditory recognition after seizure sonification. The waEEG recording was acquired with two scalp electrodes. Automatic analysis was performed using...


Hypermediation functionalities in digital platforms for collaborative and socia...

Oliveira, Eliza R.; Tymoshchuck, Oksana; Sacramento, Eveline R.; Branco, André C.; Carvalho, Daniel; Pedro, Luis; Antunes, Maria; Almeida, Ana

The purpose of this article is to identify how Mobile Apps/Platforms have promoted Hypermediation Processes, establishing functionalities that enhance hypermediation. This determines how it improves interactions and audience engagement with online media content, allowing the user to not only be a passive spectator but also actively participate through the interaction provided by the system. Considering that the...


Enhancing the longevity and functionality of Ti-Ag dry electrodes for remote bi...

Carvalho, Daniel; Marques, Sandra Mariana Silva; Siqueira, Giorgia; Ferreira, Armando José Barros; Santos, João; Geraldo, Dulce

This study aims to evaluate the lifespan of Ti-Ag dry electrodes prepared using flexible polytetrafluoroethylene (PTFE) substrates. Following previous studies, the electrodes were designed to be integrated into wearables for remote electromyography (EMG) monitoring and electrical stimulation (FES) therapy. Four types of Ti-Ag electrodes were prepared by DC magnetron sputtering, using a pure-Ti target doped with...


Highlights da monitorização EEG contínua na abordagem do estado de mal não conv...

Amaro, Catarina; Faria, Ana Rita; Gonçalves, Catarina; Carvalho, Daniel

O Estado de Mal não convulsivo (EMNC) é definido como um padrão crítico identificado no eletroencefalograma (EEG) e caraterizado por alterações do estado da consciência e, em alguns casos, sinais motores subtis. Devido à evolução dos equipamentos de EEG, atualmente é possível realizarse o registo EEG por períodos prolongados (de horas a dias). Esta evolução levou ao aumento do uso do eletroencefalograma contínu...


High incidence of early thalamic lesions in the Continuous Spike-Wave related w...

Carvalho, Daniel; Mendonça, Carla; Carvalho, João; Martins, Ana; Leal, Alberto

Objective: Continuous Spike-Wave during slow Sleep (CSWS) syndrome associates a clinically important neurocognitive regression with strong activation of non-REM sleep spikes. Its mechanisms remain unknown, but a contribution of rare perinatal thalamic injuries has been highlighted. We determine the incidence of such lesions in a cohort of CSWS patients. Methods: N = 65 patients with CSWS and a control group (N ...


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