8 documents found, page 1 of 1
Massive Osteolytic Lesion of the Femur after Total Knee Arthroplasty.
Cardoso, A; Amaro, P; Gamelas, P; Carvalho, E; Silva, R; Oliveira, MH; Jesus, MVarious failure mechanisms have been identified in total knee arthroplasty (TKA). We hereby present one case of failure, which stands out because of its rapid and destructive progression. We report the case of a 72-year-old Caucasian female patient who developed a large bone osteolytic lesion of the femur after TKA. The patient presented to our hospital 7 years after the initial surgery, complaining of persiste...
Sulforaphane prevents age-associated cardiac and muscular dysfunction through N...
Bose, C; Alves, I; Singh, P; Palade, PT; Carvalho, E; Børsheim, E; Jun, SR; Cheema, A; Boerma, M; Awasthi, S; Singh, SPAge-associated mitochondrial dysfunction and oxidative damage are primary causes for multiple health problems including sarcopenia and cardiovascular disease (CVD). Though the role of Nrf2, a transcription factor that regulates cytoprotective gene expression, in myopathy remains poorly defined, it has shown beneficial properties in both sarcopenia and CVD. Sulforaphane (SFN), a natural compound Nrf2-related act...
Establishing a link between endothelial cell metabolism and vascular behaviour ...
Silva, C; Sampaio-Pinto, V; Andrade, S; Rodrigues, I; Costa, R; Guerreiro, SG; Carvalho, E; Pinto-do-Ó, P; Nascimento, DS; Soares, RBackground/Aims: Vascular complications contribute significantly to the extensive morbidity and mortality rates observed in people with diabetes. Despite well known that the diabetic kidney and heart exhibit imbalanced angiogenesis, the mechanisms implicated in this angiogenic paradox remain unknown. In this study, we examined the angiogenic and metabolic gene expression profile (GEP) of endothelial cells (ECs)...
Glucose uptake and lipid metabolism are impaired in epicardial adipose tissue f...
Burgeiro, A; Fuhrmann, A; Cherian, S; Espinoza, D; Jarak, I; Carvalho, RA; Loureiro, M; Patrício, M; Antunes, MJ; Carvalho, EType 2 diabetes mellitus is a complex metabolic disease, and cardiovascular disease is a leading complication of diabetes. Epicardial adipose tissue surrounding the heart displays biochemical, thermogenic, and cardioprotective properties. However, the metabolic cross-talk between epicardial fat and the myocardium is largely unknown. This study sought to understand epicardial adipose tissue metabolism from heart...
Impact of EGFR genetic variants on glioma risk and patient outcome
Costa, BM; Viana-Pereira, M; Fernandes, R; Costa, S; Linhares, P; Vaz, R; Pinheiro, C; Lima, J; Soares, P; Silva, A; Pardal, F; Amorim, J; Nabiço, RBACKGROUND: The epidermal growth factor receptor (EGFR) regulates important cellular processes and is frequently implicated in human tumors. Three EGFR polymorphisms have been described as having a transcriptional regulatory function: two single-nucleotide polymorphisms in the essential promoter region, -216G/T and -191C/A, and a polymorphic (CA)(n) microsatellite sequence in intron 1. We aimed to elucidate the...
Prognostic value of MGMT promoter methylation in glioblastoma patients treated ...
Costa, BM; Caeiro, C; Guimarães, I; Martinho, O; Jaraquemada, T; Augusto, I; Castro, l; Osório, L; Linhares, P; Honavar, M; Resende, M; Nabiço, RGlioblastoma (GBM) is the most common and aggressive primary brain tumor. The identification of novel molecular prognostic markers of GBM has recently been an area of great interest in neuro-oncology. The methylation status of the MGMT gene promoter is currently a promising molecular prognostic marker, but some controversial data have precluded its clinical use. We analyzed MGMT methylation by methylation-speci...
The mechanism of hydrolysis of aryl ether derivatives of 3-hydroxymethyltriazenes
Carvalho, E; Francisco, AP; Iley, J; Rosa, E1-Aryl-3-aryloxymethyl-3-methyltriazenes hydrolyse to the corresponding anilines and phenols by specific-acid-catalysed, general-acid-catalysed and pH-independent mechanisms. All compounds studied exhibit specific- and general acid catalysis, though for 5a general acid catalysis was not observed below a pH of approximately 4, while for compounds 5e,f, such catalysis was absent above a pH of approximately 5. The...
Triazene drug metabolites. Part 17
Carvalho, E; Francisco, AP; Iley, J; Rosa, EA series of 3-acyloxymethyloxycarbonyl-1-aryl-3-methyltriazenes 5 was synthesised by the sequential reaction of 1-aryl-3-methyltriazenes with (i) chloromethyl chloroformate, (ii) NaI in dry acetone, and (iii) either the silver carboxylate or the carboxylic acids in the presence of silver carbonate. The hydrolysis of these compounds was studied in pH 7.7 isotonic phosphate buffer and in human plasma. Triazene ac...