Encontrados 23 documentos, a visualizar página 1 de 3
Enhancement of wound healing in diabetic mice by topical use of a peptide-ionic...
Gomes, Ana; Leal, Ermelindo C.; Ferraz, Ricardo; Calheiros, Daniela; Silva, Jessica da; Gonçalves, Teresa; Teixeira, Inês; Carvalho, EugéniaDiabetic foot ulcers (DFU) are one of the most devastating complications of diabetes, with high impact on patient’s quality of life. In worst scenarios, DFU can lead to severe amputation or even death. DFUs are an easy target for microbial pathogens and their effective healing is hampered by the galloping increase of microbial resistance to antibiotics, including from the most prevalent pathogens in DFU, e.g. S...
Impact of psychological distress on physiological indicators of healing prognos...
Da Silva, Jessica; Santos, Diana; Vilaça, Margarida; Carvalho, André; Carvalho, Rui; Jesus Dantas, Maria de; Pereira, M. Graça; Carvalho, EugéniaObjective: Diabetic foot ulcers (DFUs) are devastating complications of diabetes, responsible for a high number of amputations worldwide. Due to its impact on chronic inflammation, psychological distress may negatively impact the healing process. Thus, this study evaluated the influence of psychological distress on physiological indicators of healing prognosis and the potential of stress-reducing therapies for ...
Changes in metabolic and inflammatory markers after a combined exercise program...
Silva, Fernanda; Duarte-Mendes, Pedro; Ferreira, José P.; Carvalho, Eugénia; Monteiro, Diogo; Massart, Alain; Farinha, Carlos; Soares, Carlos M.Purpose: We investigated the effects of a 16-week combined exercise training on body composition, metabolic and inflammatory markers in sedentary middle-aged workers. We also assessed whether significant alterations in metabolic markers were associated with changes in health-related outcomes. Methods: This randomized controlled trial involved 46 participants randomly allocated into control and exercise groups. ...
Association between COVID-19 and the incidence of type 1 diabetes in Portugal –...
Andersen, Morten Bjerregaard; Silva, Jessica Da; Diogo,. Rui; Claro, Ana Raquel; Ferro, Inês; Romana, Andreia; Rocha, Patrícia; Sá, BeatrizBackground: Viral respiratory infections may precipitate type 1 diabetes (T1D). A possible association between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, and the incidence of T1D is being determined. This study was carried out using Portuguese registries, aiming at examining temporal trends between COVID-19 and T1D.MethodsHospital data, comparing the in...
Healing profiles in patients with a chronic diabetic foot ulcer: an exploratory...
Pereira, M. Graça; Vilaça, Margarida; Braga, Diogo; Madureira, Ana; Silva, Jéssica da; Santos, Diana; Carvalho, EugéniaDiabetic foot ulcers (DFU) are one of the most frequent and debilitating complications of diabetes. DFU wound healing is a highly complex process, resulting in significant medical, economic and social challenges. Therefore, early identification of patients with a high-risk profile would be important to adequate treatment and more successful health outcomes. This study explores risk assessment profiles for DFU h...
Peptide conjugates for the topical treatment of infected wounds
Gomes, Ana; Fernandes, Iva; Bessa, Lucinda; Ferreira, Mariana; Maciel, Joana; Plácido, Alexandra; Teixeira, Cátia; Leal, Ermelindo; Ferraz, RicardoDue to widespread multidrug-resistant (MDR) microbes, efficient treatments for infected wounds are being exhausted.1 The symptoms of wound infection are consistent with local polymicrobial biofilms, which are difficult to eliminate and delay the healing process. The current standard of care requires oral antibiotics and other measures, often complex and distressing (e.g., amputations). A perfect treatment shoul...
Stress-reducing psychological interventions as adjuvant therapies for diabetic ...
Pombeiro, Isadora; Moura, Joao; Pereira, M. Graça; Carvalho, EugéniaBackground: Diabetic foot ulcers (DFUs) are a major complication of diabetes mellitus and a leading cause of lower limb amputation. Interventions to reduce psychological stress may have the potential to improve self-care and greatly reduce the morbidity and mortality associated with DFU. This review is focused on the consequences of psychological stress in wound healing and reflects on the effects of currently ...
Effectiveness of two stress reduction interventions in patients with chronic di...
Pereira, M. Graça; Vilaça, Margarida; Carvalho, EugéniaDiabetic foot ulcer (DFU) is the leading cause of lower-limb amputations, with a significant impact on patients, families, and society. Since DFU medical treatments represent a major socioeconomic burden, cost-effective interventions are needed. This trial aims to assess the effectiveness of a muscle relaxation intervention compared to a hypnosis intervention versus active and passive control groups on DFU heal...
Effects of combined training during the COVID-19 pandemic on metabolic health a...
Silva, Fernanda M.; Duarte-Mendes, Pedro; Carvalho, Eugénia; Soares, Carlos M.; Farinha, Carlos; Serrano, João; Paulo, Rui; Massart, AlainThis study aimed to analyze the effects of a combined training (CT) program performed during the first national lockdown due to the COVID-19 pandemic on body composition, metabolic profile, quality of life and stress in sedentary workers, and examines whether changes in the metabolic profile are associated with changes in health-related outcomes which are modifiable by exercise. We evaluated 31 sedentary worker...
Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabeti...
Seraphim, Patricia M. [UNESP]; Leal, Ermelindo C.; Moura, João; Gonçalves, Pedro; Gonçalves, Jenifer P.; Carvalho, EugéniaMade available in DSpace on 2020-12-12T02:09:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-08-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); AIMS: This study aimed to investigate the effect of lymphocytes in wound healing and the underlying mechanisms, in diabetic and non-diabetic mice, using Balb/c recombination activating gene (Rag)-2 and interleukin 2 receptor gamma (IL...