55 documents found, page 1 of 6
Non-invasive bladder cancer detection: identification of a urinary volatile bio...
Carapito, Â.; Ferreira, V. S. Fernandes; Ferreira, A. C. Silva; Teixeira-Marques, A.; Henrique, R.; Jerónimo, C.; Roque, A. C. A.; Carvalho, F.Early detection of bladder cancer (BC) remains a major clinical challenge due to the limitations of current diagnostic methods, which are often invasive, expensive, or insufficiently sensitive, particularly for early-stage disease. Metabolomics approaches, when integrated with machine learning (ML) techniques, offer a powerful platform for identifying novel, non-invasive biomarkers. In this study, urinary volat...
P03-10 Synthetic cannabinoids & neuronal senescence: distinctive responses of i...
Bravo, R. Roque; Carmo, H.; Silva, J.P.; Carvalho, F.; Silva, Diana Dias da; Dias da Silva, Diana CristinaAmong the array of new psychoactive substances, synthetic cannabinoids (SC) stand out as highly popular among consumers. These substances closely resemble, in terms of their pharmacology, Δ9-tetrahydrocannabinol (THC), cannabis’ main active principle, albeit exhibiting full agonism at the cannabinoid receptors 1 and 2. In light of recent scientific findings suggesting that cannabis use can exacerbate ageing-rel...
Non-interactive effects drive multiple stressor impacts on the taxonomic and fu...
Lourenço, J.; Gutiérrez-Cánovas, C.; Carvalho, F.; Cássio, Fernanda; Pascoal, Cláudia; Pace, GiorgioFreshwaters are considered among the most endangered ecosystems globally due to multiple stressors, which coincide in time and space. These local stressors typically result from land-use intensification or hydroclimatic alterations, among others. Despite recent advances on multiple stressor effects, current knowledge is still limited to manipulative approaches minimizing biological and abiotic variability. Thus...
Cardiac mitochondrial dynamics, autophagy and regeneration are stirred by doxor...
Brandão, S. R.; Reis-Mendes, A.; Neuparth, M. J.; Carvalho, F.; Ferreira, R.; Costa, V. M.Background: The chemotherapeutic agent doxorubicin (DOX) has been widely used in the treatment of solid tumors and hematological malignancies [1]. However, serious adverse side effects have emerged in patients treated with this drug, notably cardiotoxicity [2]. Moreover, aging is a risk factor for the development of cardiovascular diseases in cancer treated patients [3]. Objective: We herein aimed to evaluate t...
The influence of glutathione pathway modulators on the cytotoxicity of sunitini...
Vitorino-Oliveira, C.; Kahremany, S.; Nisim, L.; Duarte-Araújo, M.; Carvalho, F.; Gruzman, A.; Costa, V. M.Background: Cancer survivorship has grown over the years due to more efficacious treatments. Nonetheless, anticancer treatments present serious adverse effects, namely cardiotoxicity. Doxorubicin (DOX), a topoisomerase II inhibitor; sunitinib (SUN), a multikinase inhibitor; and bortezomib (BTZ), an inhibitor of proteasome, have their clinical use limited because of their cardiotoxicity. Cardiotoxicity is often ...
Toxicity of amphetamine-type drugs in rat cardiomyocyte cells involves oxidativ...
Valente, M. J.; Araújo, A. M.; Carvalho, F.; Carvalho, M.Background: Synthetic cathinones (SCs) are recreational psychoactive substances with pharmacological properties resembling those of classical amphetamines, such as 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) [1]. Although the use of SCs has been linked to adverse health outcomes, including myocardial infarction and sudden cardiac deaths [2], the underlying cardiotoxic mechanisms are still unknown. Objecti...
The synthetic cannabinoids ADB-FUBINACA and AMB-FUBINACA accelerate SH-SY5Y pro...
Dias-da-Silva, D.; Roque-Bravo, R.; Silva, J. P.; Carmo, H.; Carvalho, F.Background: Synthetic cannabinoids (SC), one of the most popular groups of new psychoactive substances, display a broad pharmacological action close to that of D9-tetrahydrocannabinol (THC). However, while THC is a partial agonist of the cannabinoid receptors type 1 and 2 (CB1 and CB2, respectively), SC present a full and more potent agonistic activity on these receptors [1]. Since new evidence demonstrates tha...
Alterações morfométricas na retina, coroide e nervo ótico após infeção por SARS...
Lino, Pedro; Camacho, Pedro; Mendonça, Paula; Silva, Carina; Cunha, João Paulo; Barroqueiro, Olga; Condado, P.; Nicho, I.; Carmo, R.; Castelhano, M.O novo coronavírus responsável pela síndrome respiratória aguda grave (SARS-CoV- 2) surgiu associado à pandemia por COVID-19. A enzima conversora da angiotensina 2 (ACE-2), com aparente importância na COVID-19, pela interação com as proteínas na superfície do vírus, tem expressão em vários tecidos oculares e várias alterações como conjuntivite, uveíte, vasculite e neurite foram descritas inicialmente em modelos...
Learning preferences in higher education accounting courses in Portugal
Campos, F.; Carvalho, F.; Domingos, R.; Azevedo, G.; Bandeira, A.M.; Góis, C.Generation after generation, learning preferences tend to change and teaching strategies in accounting are increasingly being debated among authors. Understanding how students retain the knowledge that is imparted to them is essential for teachers to develop innovative strategies. Currently, the biggest challenge is to understand the learning preferences of Generation Z students, known as the pragmatic generati...
Associations between social anxiety and avoidance, attachment styles and parent...
Maia, B. Rodrigues; Coelho, C.; Marques, M.; Carvalho, F.Introduction: The relation between insecure general attachment and social anxiety has long been established. Objectives: To explore the associations between social interaction and performance anxiety and avoidance, attachment styles, and parental marital status. Methods: 146 Portuguese adolescents, with a mean age of 18.99 years old (SD = .848; range: 18-20), filled in the Social Interaction and Performance Anx...