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CD8+T cell profiles in patients with rheumatoid arthritis and their relationshi...
Carvalheiro, Helena; Duarte, Cátia; Silva-Cardoso, Sandra; Silva, José A. P. da; Souto-Carneiro, M. MargaridaObjective CD8+T cells are abundant in rheumatoid arthritis (RA). However, their role in the disease pathogenesis is poorly defined. Here we investigated the relationship between disease activity and CD8+T cell phenotypes, production of cytokines and cytotoxic molecules in RA peripheral blood (PB) and synovial fluid (SF). Methods CD8+T cell phenotypes were determined in 96 patients with RA (44 in remission, 34 w...
Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse mod...
Raposo, Bruno R.; Rodrigues-Santos, Paulo; Carvalheiro, Helena; Água-Doce, Ana M.; Carvalho, Lina; Pereira da Silva, José A.; Graça, LuísObjective. CD8+ T cells are part of the T cell pool infiltrating the synovium in rheumatoid arthritis (RA). However, their role in the pathogenesis of RA has not been fully delineated. Using the K/BxN mouse model of spontaneous chronic arthritis, which shares many similarities with RA, we studied the potential of CD8 T cell depletion with monoclonal antibodies (mAb) to stop and reverse the progression of experi...
Alterations in peripheral blood memory B cells in patients with active rheumato...
Souto-Carneiro, M. Margarida; Mahadevan, Vijayabhanu; Takada, Kazuki; Fritsch-Stork, Ruth; Nanki, Toshihiro; Brown, Margaret; Fleisher, Thomas A.INTRODUCTION: Disturbances in peripheral blood memory B cell subpopulations have been observed in various autoimmune diseases, but have not been fully delineated in rheumatoid arthritis (RA). Additionally, the possible role of tumour necrosis factor (TNF) in regulating changes in specific peripheral blood memory B cell subsets in RA is still unclear. METHODS: The frequency and distribution of B cell subsets in ...