10 documents found, page 1 of 1
Pharmacological NF-κB inhibition decreases cisplatin chemoresistance in muscle-...
Gil da Costa, Rui; Levesque, C; Bianchi-Frias D; Chatterjee, P; Lam, HM; Santos, C; Coleman, IM; Ferreirinha, P; Vilanova, M; Pinto da Cunha, NMost patients with muscle-invasive bladder cancer (MIBC) are not cured with platinum chemotherapy. Up-regulation of nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) is a major mechanism underlying chemoresistance, suggesting that its pharmacological inhibition may increase platinum efficacy. NF-κB signaling was investigated in two patient cohorts. The Cancer Genome Atlas (TCGA) was used to...
Health outcomes in long-term healthcare units: the case of the Care4Value project
Leal, Susana; Bernardes De Oliveira, Sandra Margarida; Querido, A; Sargento, A; Carvalho, H; Reis, C; Maximiano, M; Frederico, MIntroduction One of the objectives of the Care4Value project is to assess the health outcomes in long-term care units. Measuring health care outcomes in long-term healthcare units is a complex process due to the diversity and complexity of diseases as well as the high prevalence of terminally ill patients. Objective This study aims to develop and empirically test an index of health outcomes (IHO) in long-term h...
Trends in primary angioplasty in Portugal from 2002 to 2013 according to the Po...
Pereira, H; Teles, R; Costa, M; Silva, P; Ribeiro, V; Brandão, V; Martins, D; Matias, F; Pereira-Machado, F; Baptista, J; Abreu, PF; Santos, RIntroduction and Objectives: The aim of the present paper was to report trends in coronary angioplasty for the treatment of ST-elevation myocardial infarction (STEMI) in Portugal. Methods: Prospective multicenter data from the Portuguese National Registry of Interventional Cardiology (RNCI) and official data from the Directorate-General for Health (DGS) were studied to analyze percutaneous coronary intervention ...
Angioplastia primária em Portugal entre 2002-2013. Atividade segundo o Registo ...
Pereira, H; Teles, R; Costa, M; Silva, P; Ribeiro, V; Brandão, V; Martins, D; Matias, F; Pereira-Machado, F; Baptista, J; Abreu, PF; Santos, RIntrodução e objectivos: Foi nosso objectivo reportar a evolução da angioplastia coronária no tratamento do enfarte agudo do miocárdio com supradesnivelamento do segmento ST (EAMCST), entre 2002-2013. Métodos: Os dados prospectivos multicêntricos do Registo Nacional de Cardiologia de Intervenção (RNCI) e os dados oficiais da Direção Geral de Saúde (DGS) foram conjugados para estudar os procedimentos no EAMCST e...
Evolução da intervenção coronária percutânea entre 2004‐2013. Atividade em Port...
Pereira, H; Teles, R; Costa, M; Silva, P; Ferreira, R; Ribeiro, V; Santos, R; Abreu, PF; Carvalho, H; Marques, J; Fernandes, R; Brandão, V; Martins, DINTRODUCTION AND OBJECTIVES: The aim of the present paper is to report trends in Portuguese interventional cardiology from 2004 to 2013 and to compare them with other European countries. METHODS: Based on the Portuguese National Registry of Interventional Cardiology and on official data from the Directorate-General of Health, we give an overview of developments in coronary interventions from 2004 to 2013. RESUL...
Posição sobre suportes vasculares restaurativos transitórios coronários em Port...
Teles, R; Pereira, H; Carvalho, H; Patricío, L; Santos, R; Baptista, J; Pipa, J; Abreu, PF, et al.BACKGROUND: Bioresorbable vascular scaffolds (BVS) were recently approved for percutaneous coronary intervention in Europe. The aim of this position statement is to review the information and studies on available BVS, to stimulate discussion on their use and to propose guidelines for this treatment option in Portugal. METHODS AND RESULTS: A working group was set up to reach a consensus based on current evidence...
Posição sobre suportes vasculares restaurativos transitórios coronários em Port...
Teles, R; Pereira, H; Carvalho, H; Patrício, L; Santos, R; Baptista, J; Pipa, J; Abreu, PF; Faria, H; Ramos, S; Ribeiro, V; Martins, D; Almeida, MIntrodução: Os suportes vasculares restaurativos transitórios (sVRT) foram recentemente aprovados para intervenção coronária percutânea (ICP) na Europa e possuem propriedades muito inovadoras. O objetivo desta declaração de posição é rever criticamente a informação e os estudos com os sVRT disponíveis e contribuir para uma reflexão científica que promova o seu uso racional com orientações estruturadas para a su...
Leflunomide and Polyomavirus-Associated Nephropathy in Renal Transplant
Ferreira, AC; Ferreira, A; Possante, M; Sousa, J; Viana, H; Carvalho, H; Nolasco, FPolyomavirus nephropathy is a major complication in renal transplantation, associated with renal allograft loss in 14 to 80% of cases. There is no established treatment, although improvement has been reported with a variety of approaches. The authors report two cases of polyomavirus infection in renal allograft recipients. In the first case, a stable patient presented with deterioration of renal function, worse...
Stereotactic radiosurgery in the intracranial benign neoplasms and malignant tu...
Mascarenhas, Francisco; Costa, M Sá da; Ortiz, M; Almeida, A; Carvalho, H; Ferreira, A Gonçalves; Cattoni, M BStereotactic Radiosurgery has proven to be during the last years the therapy of choice in more and more patients with benign and malignant brain tumors. The potential advantages comparatively to surgery and conventional radiotherapy made this technique a very important tool in the therapeutic armamentarium of neurooncology. This series presents the experience of treating more than 100 intracranial lesions with ...
A methodology for the diagnosis and follow-up of the evolution of acute hepatit...
Dias, J A; Medina, M; Antonio, A M; Brandão, N; Cabral, J; Carvalho, H; Gomes, J L; Gonçalves, I; Lopes, A I; Pó, IThe Working Group of the Section of Paediatric Gastroenterology and Nutrition of the Portuguese Society of Paediatrics established a protocol for the investigation of children with acute hepatitis. The main purpose of this proposal is to allow appropriate etiologic investigations and avoid unnecessary tests that are expensive and do not add relevant information for the correct follow-up of these patients.; The ...