91 documents found, page 1 of 10

Nirsevimab Effectiveness Against RSV-Related Hospitalisations in Children Under...

We assessed Nirsevimab effectiveness (NE) against respiratory syncytial virus (RSV)-related hospitalisation in eligible children (< 2 years) using a test-negative case-control design within the VigiRSV network (weeks 43/2024 to 16/2025). Among 341 participants (median age: 2 months; 91.2% without known chronic condition), 137 (40.2%) tested RSV-positive. Adjusted NE against RSV-related hospitalisation was 78.5%...

Multiple non-contiguous interstitial deletions in 5q21q22.1, including the CHD1...

Intellectual disability (ID), developmental delay (DD), and behavioural disorders are complex neurodevelopmental conditions associated with multifactorial etiologies, including genetic factors. Chromosomal microarray analysis (CMA) is a valuable tool in identifying copy number variations (CNVs) contributing to neurodevelopmental disorders. Here we report a 4-year-old male with DD, severe language impairment, be...

Multifaceted impact of exogenous salicylic acid on vicia faba l. under salt str...

Purpose This study investigated the effect of salt stress on growth, water status, and photosynthetic activity in faba bean plants and the role of salicylic acid (SA) in mitigating the harmful effects of salt stress. Methods Faba bean plants were subjected to different levels of salt stress (0, 90, 120, and 150 mM NaCl) and salicylic acid (0, 0.5, and 1 mM SA). Salt and SA treatments were applied starting from ...

Missense variant in TTBK2 kinase domain causes loss of function and impaired pr...

Tau tubulin kinase 2 (TTBK2) is a ubiquitous serine-threonine protein kinase implicated in diverse cellular processes, including microtubule regulation, ciliogenesis, synaptic signaling, and the phosphorylation of key proteins like TDP-43. Despite its relevance, many aspects of TTBK2 function in both physiological and pathological conditions remain poorly understood. Truncating variants in TTBK2 gene cause spin...

Atypical Parkinsonism Presenting with Isolated Gaze Palsy

Peri-Lead Edema After Deep Brain Stimulation Surgery for Parkinson Disease: A M...

Deep brain stimulation (DBS) is a well-established surgical treatment for Parkinson’s disease. Peri-lead edema (PLE) is a poorly understood complication of DBS. We hereby report three cases of unilateral PLE after bilateral subthalamic nucleus (STN)-DBS and discuss its diagnosis and management. Patient 1 reported a new-onset headache one month after his surgical procedure. Antibiotic treatment was administered....

How Pandemics and Disease Outbreaks Impact the Tourism Industry: an industry pe...

The global pandemic was a disaster for humankind, but it was also a source of opportunities and challenges for society. There is a large body of research about the impacts of pandemics and disease outbreaks in tourism, especially in the consumer perspective, but less attention was paid to the perspectives of tourism players, especially the challenges and opportunities brought about by the pandemic. Using a pane...

Dietary tryptophan intervention counteracts stress-induced transcriptional chan...

Immune nutrition is currently used to enhance fish health by incorporating functional ingredients into aquafeeds. This study aimed to investigate the connections between tryptophan nutrition and the network that regulates the communication pathways between neuroendocrine and immune systems in European seabass (Dicentrarchus labrax). When tryptophan was supplemented in the diet of unstressed fish, it induced cha...

Dietary tryptophan intervention counteracts stress-induced transcriptional chan...

Immune nutrition is currently used to enhance fish health by incorporating functional ingredients into aquafeeds. This study aimed to investigate the connections between tryptophan nutrition and the network that regulates the communication pathways between neuroendocrine and immune systems in European seabass (Dicentrarchus labrax). When tryptophan was supplemented in the diet of unstressed fish, it induced cha...

Relatório de Ensino Clínico - Integração à Vida Profissional

O Ensino Clínico (EC) em contexto hospitalar decorreu entre o período de 21 de fevereiro a 29 de abril no Centro Hospitalar Universitário Cova da Beira (CHUCB) – Hospital Pêro da Covilhã, no Serviço de Medicina II e entre os dias 2 de maio a 1 de julho em contexto de Cuidados de Saúde Primários na Unidade de Cuidados de Saúde Personalizados (UCSP) Chaves II. Este EC – IVP retrata o desenvolvimento da identidade...