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Selumetinib for plexiform neurofibromas in neurofibromatosis type 1: a single-i...

Espirito Santo, Vera; Passos, Joao; Nzwalo, Hipólito; Carvalho, Ines; Santos, Filipa; Martins, Carmo; Salgado, Lucilia; Silva, Conceicao e

Background Plexiform neurofibromas (PN) are the most frequent tumors associated with Neurofibromatosis type 1 (NF-1). PN can cause significant complications, including pain, functional impairment, and disfigurement. There is no efficient medical treatment and, surgical resection of large PN is frequently infeasible. Selumetinib (AZD6244/ARRY-142886) is a mitogen-activated protein kinase enzyme (MEK1/2) inhibito...

Date: 2020   |   Origin: Sapientia - Universidade do Algarve
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