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New disinfectant for greywater systems: evaluation of antibacterial activity

Castro, Débora; Ferreri, Isabel; Henriques, Mariana; Carvalho, Isabel

In favourable environments, microorganisms can persist or proliferate within biofilms that coat the insides of pipes in greywater systems over extended periods. This study aimed to develop an innovative disinfectant that adheres strongly to PVC pipes and exhibits superior antibacterial properties. Standard tests and protocols were employed to evaluate its effectiveness against biofilms during formation and pre-...


CUsKit: a test to revolutionise the evaluation of the disinfection process

Castro, Débora; Ferreri, Isabel; Henriques, Mariana; Carvalho, Isabel

The overuse of surface disinfectants has been shown to lead to increased microbial resistance, often due to their incorrect application. The aim of this work was to develop and investigate the use of an indicative detection kit for hydrogen peroxide-based disinfectants on porous and non-porous surfaces. The detection kit allows for the detection of the disinfectant up to 7 days after its application, resulting ...


Multifunctional alumina scaffolds with enhanced bioactivity and antimicrobial p...

Santo, Daniela; Rodarte, Mikhael; Andreto, Crislayne; Cavaleiro, Diogo; Carvalho, Isabel; Balestra, Roseli; Carvalho, Sandra

Inert ceramic implants suffer from significant complications such as lack of osseointegration, biofilm formation, and infections, necessitating the development of novel materials with both osteogenic and antibacterial properties to prevent implant failure. In this study, we aimed to multifunctionalize a tridimensional macroporous alumina scaffold with a biomimetic calcium phosphate (CaP) coating combined with a...


Customisation of PVD coatings for biomedical devices

Santo, Daniela; Castro, José D.; Cruz, Sandra; Carvalho, Isabel; Cavaleiro, Albano; Carvalho, Sandra

In recent years, physical vapor deposition (PVD) has emerged as a powerful technique for surface modification, offering a wide range of possibilities to improve the properties of medical devices. This review explores the fundamentals and versatility of PVD coatings in biomedical applications, highlighting their potential to revolutionise the field. Biocompatibility is crucial in successfully integrating medical...


Molecular characterization and virulence profile of Klebsiella pneumoniae and K...

Castro, Joana Isabel Reis; Oliveira, Ricardo; Fernandes, Liliana Sousa; Carvalho, Isabel; Oliveira, Hugo Alexandre Mendes; Brinks, Erik; Cho, Gyu-Sung

Klebsiella spp. are important pathogens of humans and companion animals such as cats and dogs, capable of causing severe life-threatening diseases. The aim of this study was to characterize the molecular and phenotypic properties of Klebsiella pneumoniae and Klebsiella oxytoca isolated from ill companion animals by whole genome sequencing, followed by in vitro assessment of biofilm formation and in vivo pathoge...


Unleashing the antibiofouling potential of nano-structured ZrN-Cu coating throu...

Castro, José D.; Carvalho, Isabel; Sánchez-López, J. C.; Rojas, T. C.; Escobar-Galindo, R.; Carvalho, S.

The world needs more environmentally friendly materials every time, especially when the application demands constant interaction with fragile habitats. The naval industry is a crucial player in a globalised economy, and the ambient impact of ships on the seas is well-known. Biofouling is one of the significant issues in this industry, and paints with biocides are used as the principal coating solution. However,...


Anorectal melanoma: a rare entity

Relvas, Luís Miguel; Gago, Tânia; Velasco, Francisco; Barros, Sónia; Carvalho, Isabel; Caldeira, Paulo

Anorectal melanoma is a rare malignant tumor with the potential of simulating a benign anorectal disease, making its diagnosis difficult. We describe a case of anorectal melanoma, in which the interpretation of symptoms as hemorrhoidal disease delayed diagnosis and appropriate intervention.


The Pediatric Perspective: A Comment on “Tuberculosis Screening of Ukrainian Re...

Barros, Marta; Sousa, Margarida; Barbosa, Luciana; Carvalho, Isabel

N/a.; N/a.

Date: 2023   |   Origin: Acta Médica Portuguesa

Disseminated tuberculosis in an infant – Case report

Abreu, Ana Margarida; Miranda, Sofia; Carvalho, Isabel; Gonçalves, Augusta; Branco, Liliana; Barros, Daniela; Pinheiro, Marina

Infants are a particularly vulnerable group for the development of severe and/or extrapulmonary forms of tuberculosis. The difficulty in establishing a definitive and timely diagnosis contributes to the high morbimortality in this age group. Investigation often relies on a high index of suspicion. Herein is reported a case of disseminated tuberculosis in an infant that highlights its clinical complexity and dia...


The Importance of Context for Sentiment Analysis in Dialogues

Carvalho, Isabel; Oliveira, Hugo Gonçalo; Silva, Catarina

Sentiment Analysis (SA) can be applied to dialogues to determine the emotional tone throughout the conversation. This is beneficial for dialogue systems because it may improve humancomputer interaction. For instance, in case of negative sentiment, the system may switch to a human operator who can handle the situation more effectively. However, given that dialogues are a series of utterances, the context, includ...


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