4 documents found, page 1 of 1
Synthesis, Characterization, and Biological Effects of Chloro-Cathinones: Toxic...
Gomes, Ana Patrícia; Ferro, Raquel; Pinto, Daniela; Silva, Joana; Alves, Celso; Pacheco, Rita; Gaspar, HelenaCathinones, a class of synthetic new psychoactive substances (NPSs), continue to emerge and pose public threats. Government control efforts often lead to the emergence of new isomers, which have adverse repercussions on NPSs identification and risk prediction. This work reports on the synthesis and structural characterization of twenty chloro-cathinones, including different isomers, to create analytical data to...
Impact of the First Year of the COVID-19 Pandemic on Telestroke Network Perform...
V. Carvalho, Inês; Millet Barros, Francisco; Sousa Fernandes, Carolina; Sousa, João; Rodrigues, Ana Isabel; Faustino, Pedro; Martins, EmanuelIntroduction: Although scarce, regional telestroke networks have been developed worlwide in the last few decades. The COVID-19 pandemic put the healthcare system under exceptional pressure. We aimed to assess the impact of the first year of the COVID-19 pandemic on the telestroke network performance in the central region of mainland Portugal. Methods: Retrospective multicenter cohort study including the eight h...
Enfarte agudo do miocárdio
Gonçalves, Ana Patrícia; Pereira, Soraia; Gomes, Ana Patrícia; Lamas, MC; Mota, Sandra; Amorim, ManuelaAs cardiopatias isquémicas, nomeadamente, o enfarte agudo do miocárdio (EAM), representam uma das principais causas de mortalidade em Portugal. O EAM está associado a vários fatores de risco, dos quais alguns modificáveis e associados a estilos de vida saudável. Esta é uma das vertentes em que podemos intervir de modo a reverter esta tendência. Neste seguimento, no âmbito da unidade curricular de Educação Clíni...
Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A pos...
Teodoro, João Soeiro; Duarte, Filipe Valente; Gomes, Ana Patrícia; Varela, Ana Teresa; Peixoto, Francisco Manuel; Rolo, Anabela Pinto; Palmeira, C. M.Berberine is an isoquinoline alkaloid with anti-diabetic properties. Despite the central role of liver and thus hepaticmitochondria inwhole-bodymetabolism, berberine effects on hepaticmitochondrial function in an obesity model are still unknown. Here, we demonstrate that berberine treatment recovers mitochondrial efficiency when altered by a high-fat feeding.Mitochondria isolated from the liver of high-fat fed ...