3 documents found, page 1 of 1
Left-right side-specific endocrine signaling complements neural pathways to med...
Lukoyanov, NV; Watanabe, H; Carvalho, LS; Kononenko, O; Sarkisyan, D; Zhang, M; Andersen, MS; Lukoyanova, EA; Galatenko, V; Tonevitsky, A; Bazov, IBrain injuries can interrupt descending neural pathways that convey motor commands from the cortex to spinal motoneurons. Here, we demonstrate that a unilateral injury of the hindlimb sensorimotor cortex of rats with completely transected thoracic spinal cord produces hindlimb postural asymmetry with contralateral flexion and asymmetric hindlimb withdrawal reflexes within 3 hr, as well as asymmetry in gene expr...
Mineralocorticoid receptor antagonists eplerenone and spironolactone modify adr...
Pereira, SS; Carvalho, LS; Costa, MM; Melo, A; Ferreira, IMPLVO; Gomez-Sanchez, CE; Monteiro, MP; Vinson, G; Pignatelli, DMineralocorticoid receptor antagonists (MRAs) are a class of anti-hypertensive drugs that act by blocking aldosterone action. The aim of this study was to evaluate whether the MRAs spironolactone and eplerenone influence adrenal cortical physiology and morphology. Spontaneous hypertensive rats (SHR, n = 18) and normotensive rats (WKY, n = 18) were randomly exposed to a daily dose of spironolactone (n = 6), eple...
Left-right side-specific neuropeptide mechanism mediates contralateral response...
Watanabe, H; Nosova, O; Sarkisyan, D; Andersen, MS; Carvalho, LS; Galatenko, V; Bazov, I; Lukoyanov, NV; Maia, GH; Hallberg, M; Zhang, M; Schouenborg, JNeuropeptides are implicated in control of lateralized processes in the brain. A unilateral brain injury (UBI) causes the contralesional sensorimotor deficits. To examine whether opioid neuropeptides mediate UBI induced asymmetric processes we compared effects of opioid antagonists on the contralesional and ipsile-sional hindlimb responses to the left-sided and right-sided injury in rats. UBI induced hindlimb p...