161 documents found, page 1 of 17

Exploring cannabinoids as a novel strategy against antimicrobial resistance: a ...

Background: Natural products have been widely researched for their potential antimicrobial properties in the fight against microorganisms’ resistance to traditional drugs. Among these, cannabinoids have gained significant attention for their broad range of biological activities and their potential to enhance the effectiveness of traditional antimicrobial treatments [1]. Objective: This work presents a systemati...

Environmental exposure to metal(loid)s: an emerging risk factor for osteoporosi...

Background: Osteoporosis is a major public health concern, particularly in the aging population, due to its association with increased fracture risk and reduced quality of life [1]. Although well-established risk factors contribute to bone mineral density (BMD) loss [2], environmental exposure to metals and metalloids is an emerging but underexplored determinant. Objective: To evaluate the association between e...

Metagenomic analysis of the effects of plant- and yeast-based formulations on t...

Grapevine is highly susceptible to fungal diseases such as downy mildew and powdery mildew, which are traditionally managed through the intensive use of chemical fungicides. However, in the context of increasingly sustainable viticulture, biofungicides derived from plant and yeast extracts are gaining attention. Despite this, their impact on the grapevine leaf microbiome, crucial for plant health and disease re...

Cannabis for chronic pain: mechanistic insights and therapeutic challenges

Chronic pain represents a complex and debilitating condition that affects millions of people worldwide, significantly compromising their quality of life. The conventional approach to treating this type of pain often relies on the use of opioid analgesics and anti-inflammatory drugs. While these agents are effective in the short term, they present several limitations, including the risk of dependence, severe sid...

BlaGES-6 producing Pseudomonas aeruginosa ST235 is involved in resistance to di...

Multidrug resistance in Pseudomonas aeruginosa, particularly resistance to carbapenem, represents a major challenge for public health. This study investigated resistance mechanisms in three P. aeruginosa isolates: HU63 (blaGES-6 carbapenemase-positive), HU141 (carbapenem-resistant without carbapenemase), and PAO1 (control). Genomic analysis revealed distinct sequence types (ST235 for HU63, ST253 for HU141) and ...

KARYDAKIS FLAP ON SACROCOCCYGEAL PILONIDAL DISEASE: A BRIEF REVIEW AND DEPARTME...

Introduction: The sacrococcygeal pilonidal disease (SPD) represents a group of abscesses or sinuses with hairy content, occurring in the intergluteal cleft. Karydakis flap (KF) technique is based on the excision of SPD with a mobilized fasciocutaneous flap, with lateral suture lines. With this flap, by decreasing tension in the surgical wound, leads to less pain, faster recovery and, therefore, it reduces recur...

The unseen ingredients: a systematic review of the prevalence of microplastics ...

Background: Plastics have revolutionized every aspect of modern life [1, 2], offering convenience but also bringing forth environmental and health hazards. Their exponential production and improper disposal have led to the global burden of microplastics (MPs) and nanoplastics (NPs) in the environment [3, 4]. These tiny particles possess the alarming ability to infiltrate the food chain, thereby posing a potenti...

Bone and renal effects of low-level environmental exposure to cadmium in postme...

Background: It is widely recognized that exposure to high levels of the hazardous heavy metal cadmium (Cd) leads to renal and bone damage [1], but the association with low-level environmental exposure remains less clear. Objective: To assess the effect of environmental Cd exposure on bone and kidney function in postmenopausal women, who may already be at heightened risk of bone and kidney-related complications....

Metabolic profiling of renal cell carcinoma tissue using gas chromatography met...

Background: Renal cell carcinoma (RCC) is marked by dysregulation of angiogenesis, energy metabolism, and nutrient sensing pathways [1]. This diversity is an obstacle to achieving long-term responses to treatment, notwithstanding progress in targeted and immunotherapeutic drugs. Objective: This study aimed to characterise the metabolic dysregulations that occur in RCC tissue using a metabolomics approach. Metho...

Invisible dangers on our plates: a critical review of the widespread presence o...