3 documents found, page 1 of 1
TGFβ in malignant canine mammary tumors: relation with angiogenesis, immunologi...
Carvalho, Maria Isabel; Carvalho, Ricardo Emanuel Silva; Prada, Justina; Pinto, Carla; Gregório, Hugo; Lobo, Luis; Pires, Isabel; Queiroga, Felisbina L.Transforming growth factor- (TGF) and FoxP3 regulatory T cells (Treg) are involved in human breast carcinogenesis. This topic is not well documented in canine mammary tumors (CMT). In this work, the tumoral TGF expression was assessed by immunohistochemistry in 67 malignant CMT and its correlation to previously determined FoxP3, VEGF, and CD31 markers and other clinicopathologic parameters was evaluated. The hi...
Promotion of adjustment to the exercise of parental role in adolescence
Esteves, Inês Martins; Carvalho, Maria Isabel; Cruz, Sara Filipa; Figueiredo, MariaINTRODUCTION. Parental exercise itself constitutes a very demanding challenge – however, when pregnancy occurs in adolescence, often unplanned, it converges tasks of di'erent stages of development, irreversibly modifying an identity, roles and functions, not only of the young woman, but also of her family. OBJECTIVES. Applying the Dynamic Model of Family Assessment and Intervention (MDAIF), by Figueiredo (2012)...
EGFR and microvessel density in canine malignant mammary tumours
Carvalho, Maria Isabel; Guimarães, Maria João; Pires, Isabel; Prada, Justina; Carvalho, Ricardo Emanuel Silva; Lopes, Carlos; Queiroga, Felisbina L.The epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor which has been shown to have an important role in human breast cancer. Its role appears to be associated with increased angiogenesis and metastasis. In order to clarify its role in canine mammary tumours (CMT), 61 malignant neoplasms were studied by using immunohistochemistry, comparing expression of EGFR, microvessel densit...