13 documents found, page 1 of 2

Thrombin Generation Assay and Hemostatic Profile for Elucidating Hypercoagulabi...

Made available in DSpace on 2022-04-29T08:35:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-01; Canine hyperadrenocorticism is a common endocrine disorder caused by chronic secretion of glucocorticoid, often associated with hypercoagulability and secondary thrombosis. The thrombin generation assay (TGA) evaluates hemostasis globally by measuring endogenous thrombin potential. We aimed to determine...

Association between the use of female hormones and the thrombin generation: Cro...

Introduction: The thrombin generation assay (TGA) assesses the risk of developing thrombotic events. The aim of this study was to investigate the association between the use of oral contraceptives (OCs) and hormone therapy (HT) with the TGA and resistance to activated protein C (APC). Methods: Cross-sectional study with women from the Longitudinal Study of Adult Health (ELSA-Brasil). TGA was performed by the CA...

Associação de níveis plasmáticos de PAI- 1 e polimorfismo 4G/ 5G em pacientes c...

O polimorfismo 4G/5G do inibidor ativador do plasminogênio tipo 1 (PAI-1) pode influenciar a expressão do PAI-1. Níveis plasmáticos elevados de PAI-1 estão associados com Doença Arterial Coronariana (DAC). O presente estudo investigou a influência do polimorfismo 4G/5G do PAI-1 nos níveis plasmáticos de PAI-1 e sua associação com DAC avaliada por angiografia coronária.Foi avaliada amostra de sangue de 35 indiví...

Response to the assessment of the Matos & Carvalho index by Hoffmann and Urrech...

PAI-1 4G/5G polymorphism and plasma levels association in patients with coronar...

Type-1 plasminogen activator inhibitor (PAI-1) 4G/5G polymorphism may influence the PAI-1 expression. High plasma levels of PAI-1 are associated with coronary artery disease (CAD). This study investigated the influence of PAI-1 4G/5G polymorphism on plasma PAI-1 levels and its association with CAD assessed by coronary angiography. Blood sample of 35 individuals with angiographycally normal coronary arteries, 31...

Plasminogen and fibrinogen plasma levels in coronary artery disease

The formation of thrombi at the site of atherosclerotic lesions plays a central role in atherothrombosis. Impaired fibrinolysis may exacerbate pre-existing coronary artery disease and potentiate its evolution. While the fibrinogen plasma level has been strongly associated with the severity of coronary artery disease, its relevance in the evaluation of plasminogen in coronary artery disease patients remains uncl...

A new index to discriminate between iron deficiency anemia and thalassemia trait.

Background: The most common microcytic and hypochromic anemias are iron deficiencyanemia and thalassemia trait. Several indices to discriminate iron deficiency anemia fromthalassemia trait have been proposed as simple diagnostic tools. However, some of the bestdiscriminative indices use parameters in the formulas that are only measured in moderncounters and are not always available in small laboratories.The dev...

Clinical forms of canine visceral Leishmaniasis in naturally Leishmania infantu...

Hematological analysis has limited applications for disease diagnosis in Leishmania infantum–infected dogs, but it can be very important in evaluating the clinical forms of the disease and in understanding the evolution of canine visceral leishmaniasis (CVL) pathogenesis. Recently, we demonstrated that alterations in leucopoiesis and erythropoiesis are related to clinical status and bone marrow parasite density...

Influence of clinical status and parasite load on Erythropoiesis and Leucopoies...

Background: The bone marrow is considered to be an important storage of parasites in Leishmania -infected dogs, although little is known about cellular genesis in this organ during canine visceral leishmaniasis (CVL). Methodology/Principal Findings:The aim of the present study was to evaluate changes in erythropoiesis and leucopoiesis in bone marrow aspirates from dogs naturally infected with Leishmania chagasi...

Establishment of a microplate assay for flow cytometric assessment and it is us...

The effectiveness of flow cytometric assays for canine use is still requiring standardization. Despite several studies using purified mononuclear cells, no methodology or reference ranges are available for immunophenotyping of whole blood leukocytes (WBL). Fresh and pre-fixed WBL were used to identify cell-subsets, (Thy-1 + /CD5 + /CD4 + /CD8 + /CD21 + and CD14 + ) and measure MHC-II, CD45RA/CD45RB expression. ...