2 documents found, page 1 of 1
Chemical modifications of a natural xanthone and antimicrobial activity against...
Micheletti, Ana Camila; Honda, Neli Kika; Lima, Dênis Pires de; Beatriz, Adilson; Sant'ana, Maria Rita; Carvalho, Nádia Cristina PereiraA series of 15 ω-aminoalkoxylxanthones containing methyl, ethyl, propyl, tert-butylamino and piperidinyl moieties were synthesized from a natural xanthone isolated from a lichen species. These compounds were tested for their in vitro antibacterial properties against Gram-positive and Gram-negative bacteria and cytotoxicity against a number of human tumor cell lines was too evaluated. The newly synthesized deriv...
Constituintes químicos de Parmotrema lichexanthonicum Eliasaro & Adler - isolam...
Micheletti, Ana Carolina; Beatriz, Adilson; Lima, Dênis Pires de; Honda, Neli Kika; Pessoa, Cláudia do Ó; Moraes, Manoel Odorico deFrom the lichen Parmotrema lichexantonicum were isolated the depsidone salazinic acid, the xanthone lichexanthone, and the depside atranorin. The two major compounds, salazinic acid and lichexanthone, were selected for structure modifications. Salazinic acid afforded O-alkyl salazinic acids, some of them potentially cytotoxic against tumor cell lines (HCT-8, SF-295 and MDA/ MB - 435). From lichexanthone were ob...